Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate

Inclusion Criteria:

1. Adult 18 or over

2. Meets definition of acute sinusitis by Infectious Disease Society of America (2012)

3. Clinician and participant chose to start antibiotic treatment

Exclusion Criteria:

1. Previously enrolled in the study

2. Allergic or intolerant to amoxicillin, penicillin, or amoxicillin/clavulanate

3. Specific medication concerns: lactating (since safety of clavulanate unknown); taking
allopurinol (increased risk of rash); concurrent mononucleosis (increased risk of
rash with amoxicillin); chronic kidney disease with glomerular filtration rate < 30;
significant hepatic impairment; history of antibiotic-associated colitis

4. Cognitive impairment so that unable to give informed consent or give reliable
assessment of improvement

5. Need to use high-dose amoxicillin/clavulanate: treatment with amoxicllin or
penicillin within the past month (risk of penicillin-resistant pneumococci), very ill
patient (though not ill enough to send to hospital); immunocompromise

6. Need to hospitalize the patient