Breast Tumor Oxygenation During Exercise
| Status: | Withdrawn |
|---|---|
| Conditions: | Breast Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 21 - 70 |
| Updated: | 12/6/2017 |
| Start Date: | April 2015 |
| End Date: | January 2018 |
In the field of cancer treatment, it is generally accepted that the enhancement of oxygen
delivery to tumors can augment the effect of anti-cancer therapies. In the case of
chemotherapy, this enhancement might lead to a larger amount of a given dose of treatment
reaching the tumor and having an effect.
delivery to tumors can augment the effect of anti-cancer therapies. In the case of
chemotherapy, this enhancement might lead to a larger amount of a given dose of treatment
reaching the tumor and having an effect.
While the benefits of exercise on overall health are widely documented, little is known about
how exercise affects the progression or treatment of malignant neoplasms. Tumors have a
complex vascular network which is likely affected by the global changes in hemodynamics and
perfusion that occur during moderate exercise. Increased tumor oxygenation is clinically
relevant as it may counteract the hypoxic tumor environment which is known to contribute to
resistance to chemo- and radiation therapies, angiogenesis, invasiveness and metastasis,
genomic instability, and resistance to cell death.
The researcher can use noninvasive optical imaging technology called diffuse optical
spectroscopy to safely and non-invasively quantify the dynamics of blood flow and metabolism
in tumors and normal tissue of subjects undergoing supervised cycling exercise. The
researcher can determine that exercise will measurably increase tumor oxygenation, and that
this effect will be proportional to the intensity and/or duration of the exercise performed.
how exercise affects the progression or treatment of malignant neoplasms. Tumors have a
complex vascular network which is likely affected by the global changes in hemodynamics and
perfusion that occur during moderate exercise. Increased tumor oxygenation is clinically
relevant as it may counteract the hypoxic tumor environment which is known to contribute to
resistance to chemo- and radiation therapies, angiogenesis, invasiveness and metastasis,
genomic instability, and resistance to cell death.
The researcher can use noninvasive optical imaging technology called diffuse optical
spectroscopy to safely and non-invasively quantify the dynamics of blood flow and metabolism
in tumors and normal tissue of subjects undergoing supervised cycling exercise. The
researcher can determine that exercise will measurably increase tumor oxygenation, and that
this effect will be proportional to the intensity and/or duration of the exercise performed.
Inclusion Criteria:
- Tumor group, female, Greater than 21 years of age but less than 70 years of age,
Current diagnosis of breast cancer stage 0 - IV or radiologically suspicious for
breast cancer BI-RADS score 4 or 5.
- Control group,Female, Greater than 21 years of age but less than 70 years of age, Not
currently diagnosed with breast cancer
Exclusion Criteria:
- Under 21 years of age, Pregnant or breastfeeding, Contraindications for moderate
exercise, history of heart, pulmonary, or musculoskeletal disease; physician
instructions to restrict physical activity.
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