Energetics and Function in Older Humans
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 21 - 80 |
| Updated: | 3/1/2019 |
| Start Date: | November 2014 |
| End Date: | December 31, 2019 |
The investigators have previously reported that older patients with HIV are deficient in
glutathione (GSH) due to decreased availability of cysteine and glycine, and that oral
supplementation with cysteine (as n-acetylcysteine) and glycine for 2-weeks corrects their
own levels, and improves concentrations of red-cell GSH. The investigators also found that
when GSH deficient, subjects had impaired mitochondrial energetics and this improved with an
increase in intracellular GSH concentrations. The current proposal will investigate if
cysteine and glycine supplementation for a duration of 24 weeks will result in changes in :
(a) GSH levels; (b) body composition/anthropometry; (c) strength and function; (d) quality of
life; (e) mitochondrial energetics; (f) biochemistry (including dyslipidemia and oxidative
stress); (g) protein and glucose metabolism; (h) cognition and memory. 3 months after
completing supplementation, measurement of GSH concentrations, strength, function,
mitochondrial energetics and neurocognitive tests will be done to determine the effects of
washout.
glutathione (GSH) due to decreased availability of cysteine and glycine, and that oral
supplementation with cysteine (as n-acetylcysteine) and glycine for 2-weeks corrects their
own levels, and improves concentrations of red-cell GSH. The investigators also found that
when GSH deficient, subjects had impaired mitochondrial energetics and this improved with an
increase in intracellular GSH concentrations. The current proposal will investigate if
cysteine and glycine supplementation for a duration of 24 weeks will result in changes in :
(a) GSH levels; (b) body composition/anthropometry; (c) strength and function; (d) quality of
life; (e) mitochondrial energetics; (f) biochemistry (including dyslipidemia and oxidative
stress); (g) protein and glucose metabolism; (h) cognition and memory. 3 months after
completing supplementation, measurement of GSH concentrations, strength, function,
mitochondrial energetics and neurocognitive tests will be done to determine the effects of
washout.
Data not available at present
Inclusion Criteria:
Older subjects:
- age 70-80 years;
Younger subjects:
- age 21-30 years
Exclusion Criteria:
1. No known diabetes, liver disease, kidney disease, coronary heart disease, stroke, or
cancer;
2. Any limitations in ability to walk;
3. Triglyceride concentrations greater than 500 mg/dl (if lipid lowering medications are
stopped);
4. BMI less than 20.
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