Glutathione and Function in HIV Patients
| Status: | Active, not recruiting |
|---|---|
| Conditions: | HIV / AIDS, HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 45 - 65 |
| Updated: | 2/28/2019 |
| Start Date: | November 2014 |
| End Date: | December 2019 |
We have recently reported that older patients with HIV are deficient in glutathione (GSH) due
to decreased availability of cysteine and glycine, and that oral supplementation with
cysteine (as n-acetylcysteine) and glycine for 2-weeks corrects their own levels, and
improves (but does not fully normalize) concentrations of red-cell GSH. We also found that
when GSH deficient, subjects had impaired mitochondrial fuel oxidation and this improved with
an increase in intracellular GSH concentrations. These older HIV patients also had
significant increases in muscle strength with improvement of GSH levels.The current proposal
in older HIV patients will investigate study if cysteine and glycine supplementation for a
duration of 12 weeks will result in changes in : (a) GSH levels; (b) body
composition/anthropometry; (c) strength and function; (d) quality of life; (e) mitochondrial
energetics; (f) biochemistry (including dyslipidemia and oxidative stress); (g) protein and
glucose metabolism; (h) cognition and memory. After completing supplementation for 3 months,
GSH concentrations, strength, function, mitochondrial energetics and neurocognitive tests
will be measured for a further 2 months to determine the effects of washout.
to decreased availability of cysteine and glycine, and that oral supplementation with
cysteine (as n-acetylcysteine) and glycine for 2-weeks corrects their own levels, and
improves (but does not fully normalize) concentrations of red-cell GSH. We also found that
when GSH deficient, subjects had impaired mitochondrial fuel oxidation and this improved with
an increase in intracellular GSH concentrations. These older HIV patients also had
significant increases in muscle strength with improvement of GSH levels.The current proposal
in older HIV patients will investigate study if cysteine and glycine supplementation for a
duration of 12 weeks will result in changes in : (a) GSH levels; (b) body
composition/anthropometry; (c) strength and function; (d) quality of life; (e) mitochondrial
energetics; (f) biochemistry (including dyslipidemia and oxidative stress); (g) protein and
glucose metabolism; (h) cognition and memory. After completing supplementation for 3 months,
GSH concentrations, strength, function, mitochondrial energetics and neurocognitive tests
will be measured for a further 2 months to determine the effects of washout.
Detailed data are not as yet available
Inclusion Criteria:
HIV patients:
- age 45-65 years
Non-HIV subjects:
- age 45-65 years
Exclusion Criteria:
1. Hospitalization in the past 3 months
2. Untreated hypothyroidism or hyperthyroidism
3. Known diabetes mellitus, hypercortisolemia, coronary artery disease.
4. Known liver impairment (ALT and AST >2ULN)
5. Renal impairment (Creatinine>1.4)
6. Inability to walk
7. Patients on anticoagulation or antiplatelet therapy.
8. Patient with triglyceride concentrations >500 mg/dl.
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