A Study of Ixekizumab (LY2439821) in Participants With Active Psoriatic Arthritis
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Arthritis, Psoriasis |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Rheumatology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/16/2017 |
| Start Date: | December 2014 |
| End Date: | June 2019 |
A Multicenter, Randomized, Double-Blind, Placebo Controlled 24-Week Study Followed by Long Term Evaluation of Efficacy and Safety of Ixekizumab (LY2439821) in Biologic Disease-Modifying Antirheumatic Drug-Experienced Patients With Active Psoriatic Arthritis
The main purpose of this study is to evaluate how effective and safe the study drug known as
ixekizumab is in participants with active psoriatic arthritis.
ixekizumab is in participants with active psoriatic arthritis.
Inclusion Criteria:
- Presents with established diagnosis of active psoriatic arthritis (PsA) for at least 6
months, and currently meets Classification for Psoriatic Arthritis (CASPAR) criteria
- Active PsA defined as the presence of at least 3 tender and at least 3 swollen joints
- Presence of active psoriatic skin lesion or a history of plaque psoriasis (Ps)
- Men must agree to use a reliable method of birth control or remain abstinent during
the study
- Women must agree to use reliable birth control or remain abstinent during the study
and for at least 12 weeks after stopping treatment
- Have been treated with 1 or more conventional disease-modifying antirheumatic drugs
(cDMARDs)
Exclusion Criteria:
- Current use of biologic agents for treatment of Ps or PsA
- Inadequate response to greater than 2 biologic DMARDs
- Current use of more than one cDMARDs
- Diagnosis of active inflammatory arthritic syndromes or spondyloarthropathies other
than PsA
- Have received treatment with interleukin (IL) -17 or IL12/23 targeted monoclonal
antibody (MAb) therapy
- Serious disorder or illness other than psoriatic arthritis
- Serious infection within the last 3 months
- Breastfeeding or nursing (lactating) women
We found this trial at
62
sites
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Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Univ of North Carolina Carolina’s vibrant people and programs attest to the University’s long-standing place...
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MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
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The University of California, San Diego UC San Diego is an academic powerhouse and economic...
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Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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