Peri-operative Assessment of Coagulopathy in Neonates and Infants Undergoing Cardiac Surgery
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology, Cardiology, Hematology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Hematology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/2/2016 |
| Start Date: | January 2015 |
| End Date: | July 2015 |
| Contact: | David Faraoni, MD |
| Email: | david.faraoni@childrens.harvard.edu |
| Phone: | +1 (617) 919-3445 |
This prospective study will aim to globally assess the coagulopathy induced during cardiac
surgery with cardiopulmonary bypass (CPB) in a large pediatric population. The investigators
primary objective will be the understanding of CPB-induced coagulopathy based on demographic
and surgical characteristics, and coagulation assays. Secondary objective will aim at
determining the relationship between coagulation assays, postoperative blood loss, and
transfusion requirements. The ultimate goal will be to design an algorithm using
point-of-care monitoring that could be used to guide hemostatic therapies in neonates and
children undergoing cardiac surgery.To do this, investigators will examine the coagulation
in the laboratory based setting.
surgery with cardiopulmonary bypass (CPB) in a large pediatric population. The investigators
primary objective will be the understanding of CPB-induced coagulopathy based on demographic
and surgical characteristics, and coagulation assays. Secondary objective will aim at
determining the relationship between coagulation assays, postoperative blood loss, and
transfusion requirements. The ultimate goal will be to design an algorithm using
point-of-care monitoring that could be used to guide hemostatic therapies in neonates and
children undergoing cardiac surgery.To do this, investigators will examine the coagulation
in the laboratory based setting.
Inclusion Criteria:
- Neonates weighing greater than 2.5 kg
- Patients equal to or less than 12 months of age
- Undergoing elective cardiac surgery with cardiopulmonary bypass
Exclusion Criteria:
- Emergent procedure
- The patient is deemed to be in a moribund condition (American Society of
Anesthesiology (ASA 5))
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