Maintaining Patency in Implanted Port Catheters

The purpose of this study is to determine the safest and most effective flushing solution for
maintaining patency (unobstructed flow) in implanted port catheters. The complication rate in
patients whose ports are flushed with saline only will be compared to the complication rate
in patients whose ports are flushed with a combination of saline and heparinized saline.
These complications include partial or complete obstruction, infection of the central line,
and/or the onset of heparin induced thrombocytopenia.

Inclusion Criteria:

- Able to read and understand English

- Has an implanted port in place less than one (1) year

- Evidence of a patent (unobstructed) port catheter prior to enrollment in the study

- Is receiving active treatment (i.e., receiving a therapeutic drug through the
implanted port)

- Current treatment protocol projected to continue for a minimum of three (3) months

- Anticipates receiving care at the identified centers for 12 months following
enrollment in the study

- Does not receive care of implanted port at any other facility

Exclusion Criteria:

- Has documented heparin platelet antibody (i.e., could not be randomized to either
group) or other allergy to heparin

- Receiving therapeutic dose of an anticoagulant (e.g.,warfarin, heparin, enoxaparin)

- Does not meet one or more of the inclusion criteria