Decentralized Dietary UC Pilot Trial

Inclusion Criteria:

1. Males and females between the ages of 18 and 80, inclusive, who reside in the state of
Massachusetts.

2. Ability and willingness to provide documented informed consent and to comply with the
study procedures, including in-person visits for Arm 1 and video visits for Arm 2.

3. Documented history of moderate to severe active UC

4. Disease duration of ≥12 weeks at the time of screening (diagnosed according to
American College of Gastroenterology practice guidelines)

5. Screening fecal calprotectin>350 mg/g

6. Diagnosis of moderately to severely active UC, including historical endoscopy sub
score ≥2; a rectal bleeding sub score ≥1 and disease activity a minimum of 25 cm from
the anal verge.

7. Documented (via video or report) endoscopy performed within 2 years prior to
randomization.

8. Access to a computer or mobile device with internet connection and an active email
address.

Exclusion Criteria:

1. Prior extensive colonic resection, subtotal or total colectomy or planned surgery for
UC

2. Past or present ileostomy or colostomy

3. Short bowel syndrome

4. Diagnosis of indeterminate colitis, fulminant colitis, toxic megacolon

5. Past or present fistula or abdominal abscess

6. History or current evidence of colonic mucosal dysplasia

7. Use of tube feeding, defined formula diets or parenteral alimentation/nutrition which
has not been discontinued ≥3 weeks prior to study enrollment

8. Use of anticoagulants, herbal supplements and omega-3/fish oil supplements during the
study

9. Crohn's Disease

10. Significant uncontrolled co-morbidity, such as neurological, cardiac (e.g., moderate
to severe heart failure NYHA class III/IV), pulmonary, renal, hepatic, endocrine or
gastrointestinal disorders

11. History of alcohol, drug or chemical abuse within 6 months prior to screening

12. Pregnant females, those intending to become pregnant, and those who are lactating

13. Current participation in any other clinical trial