Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 7 - 110 |
| Updated: | 4/21/2016 |
| Start Date: | August 1991 |
| End Date: | January 2017 |
| Contact: | Jacqueline Smith |
| Email: | Jacqueline.Smith4@nyumc.org |
| Phone: | 212-263-3335 |
Quantitative MR Imaging and Proton Spectroscopy in MS
The primary purpose of this study is to detect changes in the brain that may be associated
with multiple sclerosis. Results will be compared to age matched controls. Investigators
will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization
transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and
secondary-progressive disease. This data will be correlated to total brain parenchymal
volume as well as identifying the effect of MS lesions on the gray and white matter,
volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a
specific battery of neuropsychological tests. Quantitative analysis of whole brain
N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and
compare the results to age-matched controls over duration of 5 years.
with multiple sclerosis. Results will be compared to age matched controls. Investigators
will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization
transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and
secondary-progressive disease. This data will be correlated to total brain parenchymal
volume as well as identifying the effect of MS lesions on the gray and white matter,
volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a
specific battery of neuropsychological tests. Quantitative analysis of whole brain
N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and
compare the results to age-matched controls over duration of 5 years.
Inclusion Criteria:
1. Patients with known MS diagnosis
2. Age 7-110 years
3. Males or females
Exclusion Criteria:
1. Medically unstable
2. Artificial implants in the body
3. Pregnant
Normal Controls
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