Study of Kinetics, Dosimetry & Safety of [18F]F-AraG, a Positron Emission Tomography Imaging Tracer in Healthy Humans



Status:Completed
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:5/19/2018
Start Date:February 2015
End Date:December 31, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

Study of the Kinetics, Dosimetry and Safety of [18F]F-AraG, a Positron Emission Tomography Tracer for Imaging the Activation of the Immune System in Healthy Humans

The goal of this study is to visualize biodistribution of a PET tracer called [18F]F-AraG
through time in healthy human volunteers.

A positron emission tomography (PET) imaging tracer will be intravenously injected into
healthy human volunteers who provide informed consent. Following injection of this tracer
each volunteer will have four whole-body PET scans inside a PET scanner to obtain images of
tracer biodistribution at four different time points. This will allow studying the kinetics
of the tracer as well analysis of tracer dosimetry. Safety of the tracer will also be
analyzed in each volunteer.

Inclusion Criteria:

- Healthy human subjects without history of chronic disease or at present an acute
disease will be included.

- Ability to abide by the study conditions is also a requirement for inclusion.

Exclusion Criteria:

- Individuals under the age of 18 years and pregnant women will be excluded from the
[18F]F-AraG imaging studies.

- Women who are breast-feeding will be excluded from the study.

- Individuals unable to provide informed consent will be excluded.
We found this trial at
1
site
UCSF Imaging Center at China Basin
San Francisco, California 94107
Phone: 415-353-9437
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San Francisco, CA
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