Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer

Study Groups:

If you are found to be eligible to take part in this study, you will be randomly assigned
(as in a roll of dice) to 1 of 2 groups. This is done because no one knows if one study
group is better, the same, or worse than the other group. You will have a 1 out of 3 chance
of being in Group 1 and a 2 out of 3 chance of being in Group 2.

- If you are in Group 1, you will take placebo pills.

- If you are in Group 2, you will take metformin pills.

Neither you nor the study staff will know if you are receiving the study drug or the
placebo. However, if needed for your safety, the study staff will be able to find out what
you are receiving.

Study Drug Administration:

You should take the pills 2 times a day at about the same time every day, preferably with
food (for example, with breakfast and dinner).

You will start taking the pills about 12 days before your paclitaxel treatment starts. This
is called the "adaptation period." It is meant to allow your body to get used to the study
pills. The study staff will check you for allergic reactions or other negative reactions to
the pills during this period. If you are not tolerating the pills, you will be taken off
study.

About every 3 weeks while you are receiving paclitaxel, you should bring the study
drug/placebo container (along with any leftover pills) to the clinic. The study staff will
count the number of pills you have taken.

Study Visits:

Every week during the study, either during your clinic visit or by phone, the study staff
will ask you about any side effects you may be having, if you have taken the study
drug/placebo, and how many pills you have taken so far. The calls should take about 10-15
minutes.

About 2 weeks before you start paclitaxel:

- You will complete questionnaires about numbness and other symptoms. It should take
about 15 minutes to complete these questionnaires.

- You will complete 3 sensory and fine-motor tests. These tests will show researchers how
sensitive you are to touching things such as small bumps and how well you are able to
pick up small objects. It should take about 15 minutes to complete these tests.

- If possible, blood (about 8 teaspoons) will also be drawn to test for markers of
inflammation. Markers of inflammation are biomarkers found in the blood and may be
related to the symptoms you have. These blood samples during the study will only be
collected if they can be drawn during a routine blood draw you are already having.

At 1-2 days before you start paclitaxel:

- You will complete the questionnaires about numbness and other symptoms.

- You will complete the sensory and fine-motor tests.

- Blood (about 8 teaspoons) will be drawn to test for markers of inflammation, if a
routine blood sample is also being drawn on that day.

Every week while you are receiving paclitaxel, you will complete a questionnaire in the
clinic or by phone about any symptoms you may be having, and how the symptoms may be
affecting your daily activities. This questionnaire should take about 5 minutes to complete.

About every 3 weeks while you are receiving paclitaxel, at your clinic visits:

- You will complete the questionnaires about numbness.

- You will also complete the sensory and fine-motor dexterity tests.

At about Weeks 6 and 12 while you are receiving paclitaxel, at your clinic visits, blood
(about 8 teaspoons) will be drawn to test for markers of inflammation, if a routine blood
sample is also being drawn on that day.

At about Week 12 while you are receiving paclitaxel, at your clinic visit, you will complete
a questionnaire about how satisfied you are with the study drug/placebo. Completing the
questionnaire should take about 5 minutes.

Length of Study:

You may take the study drug/placebo for up to 12 weeks. You will no longer be able to take
the study drug/placebo if the disease gets worse, if intolerable side effects occur, or if
you are unable to follow study directions.

Your participation in the study will be over after the end-of-study visit.

End-of-Study Visit:

About 4 weeks after you finish receiving the study drug/placebo:

- You will complete the questionnaires about numbness and other symptoms.

- You will complete the sensory and fine-motor tests.

- Blood (about 8 teaspoons) will be drawn to test for markers of inflammation, if a
routine blood sample is also being drawn on that day.

This is an investigational study. Metformin is FDA approved and commercially available for
the treatment of a type of diabetes. Its use in this study is investigational. The study
doctor can explain how the study drug is designed to work.

Up to 42 participants will be enrolled in this study. All will take part at the Harris
Health System.

Inclusion Criteria:

1. Patients with histologically confirmed invasive breast cancer, stage I - IV, treated
at Lyndon B. Johnson General Hospital in the Harris Health System.

2. Patients = or > 18 years old and < 75 years old.

3. Patients scheduled to undergo paclitaxel chemotherapy for breast cancer.

4. Patients with adequate renal function, as evidenced in laboratory values = or < 3
months old: eGFR = or > 60 mL/min/1.73m2.

5. Patients with adequate hepatic function per institutional testing standards, as
evidenced in laboratory values = or < 3 months old: (1) The screening results for
total bilirubin must be < 1.5 times the upper limit of normal. (2) The screening
results for aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must
be < 2 times the upper limit of normal.

6. Patients who speak English and/or Spanish.

7. Patients who are willing and able to review, understand, and provide written consent.

8. Patients with an Eastern Cooperative Oncology performance status of 0 or 1.

Exclusion Criteria:

1. Patients with a history of or known diagnosis of diabetes according to national
guidelines (fasting plasma glucose > or = 126 mg/dL or random plasma glucose > or =
200 mg/dL), as evidenced in laboratory values < or = 3 months old).

2. Patients using carbonic anhydrase inhibitors (acetazolamide [Diamox®], brinzolamide
[Azopt®], methazolamide [Neptazane®], dorzolamide [Trusopt®], pomegranate
ellagitannins), cimetidine, or topiramate.

3. Patients who are enrolled in another symptom management trial.

4. Patients with nerve pathology or clinically identified neuropathy.

5. Patients with a history of clinically significant cutaneous drug reaction,
hypersensitivity reaction, anaphylaxis, or any other serious adverse reaction to the
medication used in the study.

6. Patients with any condition associated with increased risk of metformin-associated
lactic acidosis (e.g., congestive heart failure defined as New York Heart Association
Class III or IV functional status, history of acidosis of any type).

7. Patients with intestinal issues, including malabsorption syndrome, disease
significantly affecting gastrointestinal function, or resection of the stomach or
small bowel.

8. Patients who are pregnant are excluded. Pre-menopausal women must have a negative
pregnancy test. Patients that are post menopausal, or that have had a hysterectomy do
not need to have a pregnancy test.

9. Patients with any condition that precludes use of the study medication as determined
by the treating physician.

10. Patients with a diagnosis of hepatitis or HIV.

11. Patients currently receiving or scheduled to receive a chemotherapy infusion other
than Adriamycin/Cyclophosphamide prior to initiation of the metformin adaptation
phase are not eligible. Patients who are receiving Adriamycin/Cyclophosphamide must
be scheduled to be at least 8 days post-chemotherapy infusion prior to initiation of
the metformin adaptation phase in order to be eligible.

12. Patients who are currently using metformin (eg, Fortamet, Glucophage, Glucophage XR,
Glumetza, Riomet).