A Study to Evaluate the Effect of Increased Stomach pH on Evacetrapib in Healthy Participants
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 10/5/2018 |
| Start Date: | January 2015 |
| End Date: | April 2015 |
Evaluation of the Impact of Increased Gastric pH Following Omeprazole Administration on the Pharmacokinetics of Evacetrapib in Healthy Subjects
The purpose of this study is to evaluate the effect of increased stomach pH on how much
evacetrapib is found in the blood stream and how long the body takes to get rid of it when
given to healthy participants. Information about any side effects that may occur will also be
collected.
There are two parts to the study. Participation in both parts will be required.
The study will last approximately 30 days, not including screening.
evacetrapib is found in the blood stream and how long the body takes to get rid of it when
given to healthy participants. Information about any side effects that may occur will also be
collected.
There are two parts to the study. Participation in both parts will be required.
The study will last approximately 30 days, not including screening.
Inclusion Criteria:
- Overtly healthy participants, as determined by medical history and physical
examination
- Females must be of non-child-bearing potential
- Have a body mass index of 18 to 32 kilograms per square meter (kg/m^2)
Exclusion Criteria:
- Have known allergies to evacetrapib, omeprazole, related compounds, or any components
of the evacetrapib or omeprazole formulations
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