Late Effects of Radiation Therapy and Natural History of Disease in Patients Previously Treated for Cancer at the National Institutes of Health

OBJECTIVES:

- Continue follow-up care for long-term survivors and other patients who received
radiotherapy at the National Cancer Institute's (NCI) Radiation Oncology Branch at the
National Institutes of Health (NIH) in the past and for whom continued follow-up at NIH
is considered beneficial to both the patient and the Radiation Oncology Branch.

- Assess the natural history of the disease in these patients.

- Assess late effects of treatment in these patients.

OUTLINE: Patients are evaluated by Radiation Oncology Branch staff at appropriate intervals
(based on good medical practices) to determine the natural history of the disease, long-term
effects of previous therapies, and potential eligibility for enrollment on future protocols.
Diagnostic tests, evaluations, and subsequent treatments (if needed) vary according to the
individual patient's circumstances. Data is collected to assist researchers in studying
long-term effects of radiotherapy and outcomes of the disease.

PROJECTED ACCRUAL: A maximum of 300 patients will be accrued for this study.