Lifestyle Intervention and Testosterone Replacement in Obese Seniors

Obesity is not only highly prevalent among Americans, but even more so among Veterans using
VA medical facilities. Failure to assist Veterans in managing weight and sedentary lifestyle
affects current treatment and increases future demand for VA health care services. Decreased
muscle mass with aging and the need to carry extra mass due to obesity make it particularly
difficult for obese older Veterans to function independently and results in frailty leading
to increased nursing home admissions and increased morbidity and mortality. Data from
preliminary studies showed that lifestyle therapy resulting in weight loss in this
understudied population improves physical function and ameliorates frailty. However, this
improvement in physical function is modest at best and most obese older adults remain
physically frail. More importantly, there are concerns that lifestyle therapy may exacerbate
underlying sarcopenia and osteopenia from weight loss- induced loss of lean body mass and
bone mineral density (BMD). As a result, most geriatricians are reluctant to recommend
lifestyle therapy that includes weight loss in obese frail elderly patients although the
combination of weight loss and exercise is recommended as part of standard care for obese
patients in general. Thus, it is not surprising that among Veterans, the MOVE (Managing
Overweight/Obese Veterans) program does not have any guidelines for eligible Veterans if they
are 70 or older. In addition to overeating and lack of exercise, age-related decline in
anabolic hormone (i.e. testosterone) may contribute to sarcopenia and osteopenia, which in
turn is exacerbated by obesity. Indeed, preliminary studies discovered that obese older men
had markedly low levels of serum testosterone at baseline which remained low throughout the
duration of lifestyle therapy. Because testosterone replacement therapy has been shown to
increase muscle mass and BMD, it is therefore likely that concomitant testosterone
replacement during lifestyle therapy in obese older adults would preserve lean body mass and
BMD, and reverse frailty. Accordingly, the optimal management to the problem of sarcopenic
obesity and frailty might require a comprehensive approach of a combination of lifestyle
intervention and the correction of anabolic hormone deficiency. Therefore, the primary goal
of this proposal is to conduct a randomized, comparative efficacy, double-blind,
placebo-controlled (for testosterone) trial of the effects of 1) lifestyle therapy (1%
diet-induced weight loss and exercise training) + testosterone replacement therapy versus 2)
lifestyle therapy without testosterone replacement (testosterone placebo) in obese (BMI e 30
kg/m2) older (age e 65 yrs) male Veterans. The investigators hypothesize that 1) lifestyle
therapy + testosterone replacement will cause a greater improvement in physical function than
lifestyle therapy without concomitant testosterone replacement; 2) lifestyle therapy +
testosterone replacement will cause a greater preservation of fat-free mass and thigh muscle
volume than lifestyle therapy without testosterone replacement, 3) lifestyle therapy +
testosterone replacement will cause a greater preservation in BMD and bone quality than
lifestyle therapy without testosterone replacement, and 4) lifestyle therapy + testosterone
replacement will cause a greater reduction in intramuscular proinflammatory cytokines than
lifestyle therapy without testosterone replacement. The overarching hypothesis across aims is
that a multifactorial intervention by means of lifestyle therapy plus testosterone
replacement will be the most effective approach for reversing sarcopenic obesity and frailty
in obese older male adults, as mediated by their additive effects in suppressing chronic
inflammation, and stimulating muscle and bone anabolism. Obesity in older adults, including
many aging Veterans, is a major public health problem. In fact, the public health success
that has occurred in recent years could be in danger if lifestyles of older adults are
neglected. The novel health outcomes and mechanistic-based data generated from this proposed
randomized clinical trial (RCT) will have important ramifications for the standard of care
for this rapidly increasing segment of the aging Veteran population.

Inclusion Criteria:

Subjects will be

- older (65-85 yr)

- obese (BMI 30 kg/m2 or greater) Veteran men with low testosterone (less than 300
mg/dL) as defined by the Endocrine Society

- mild to moderately frail

- must have stable weight (~not less than or more than 2 kg) during the last 6 months

- sedentary (regular exercise less than 1 h/week or less than 2x/week for the last 6
months)

Exclusion Criteria:

- Any major chronic diseases, or any condition that would interfere with exercise or
dietary restriction, in which exercise or dietary restriction are contraindicated, or
that would interfere with interpretation of results.

- Examples include, but are not limited to:

- cardiopulmonary disease (e.g. recent myocardial infarction (MI), unstable angina,
stroke etc) or unstable disease (e.g. CHF)

- severe orthopedic/musculoskeletal or neuromuscular impairments

- visual or hearing impairments

- cognitive impairment (Mini Mental State Exam Score less than 24)

- current use of bone active drugs

- uncontrolled diabetes (i.e. fasting blood glucose more than 140 mg/dl and/or
HbA1c greater than 9.5%).

- Any contraindications to testosterone supplementation

- history of prostate or breast cancer

- history of testicular disease

- untreated sleep apnea

- hematocrit more than 50%

- prostate-related findings of palpable nodule on exam, a serum PSA of 4.0 ng/ml or
greater

- International Prostate Symptom Sore more than 8

- Osteoporosis or a BMD T-score of -2.5 in the lumbar spine

- total hip

- as well as those patients with a history of osteoporosis-related fracture (spine, hip,
or wrist)