Asthma in the Elderly: A Study of Choline Supplementation
| Status: | Completed |
|---|---|
| Conditions: | Asthma |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 4/21/2016 |
| Start Date: | January 2015 |
| End Date: | June 2015 |
Asthma in the elderly is poorly understood, as most studies have not included this patient
group. In a previous study of adults with asthma, choline supplementation had a positive
effect on asthma symptoms and allowed to decrease asthma pharmacologic treatment. The
present study is a randomized, double-blind, placebo-controlled, cross-over study of choline
supplementation. The investigators will study the effect of choline 650 mg taken orally
twice daily x 6 weeks versus placebo on asthma symptom scores (Asthma Control Test) and
spirometric values (FEV1, FEV1/FVC, FEF25-75%). The investigators will also look at the
effect of choline supplementation on peripheral blood eosinophils, serum immunoglobulin E
(IgE) and homocysteine levels.
group. In a previous study of adults with asthma, choline supplementation had a positive
effect on asthma symptoms and allowed to decrease asthma pharmacologic treatment. The
present study is a randomized, double-blind, placebo-controlled, cross-over study of choline
supplementation. The investigators will study the effect of choline 650 mg taken orally
twice daily x 6 weeks versus placebo on asthma symptom scores (Asthma Control Test) and
spirometric values (FEV1, FEV1/FVC, FEF25-75%). The investigators will also look at the
effect of choline supplementation on peripheral blood eosinophils, serum immunoglobulin E
(IgE) and homocysteine levels.
Inclusion Criteria:
- Asthma
Exclusion Criteria:
- No history of smoking more than 10 pack/years,
- no gastrointestinal cancers,
- no liver or kidney disease,
- no bipolar disorder.
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