Struvite Stones Antibiotic Study

Struvite stones or infection stones are a subset of kidney stones that are related to
bacterial infection. They only make up 15% of all kidney stones, but account for a much
higher percentage of mortality (up to 67%) compared to other stones—due to the infectious
component. Treatment is to ensure 100% eradication of the stone with surgery followed by
antibiotics to eliminate the infection. Failure to eliminate the bacteria results in the
stone growing back quickly. It is unknown how long antibiotics should be administered
immediately after surgery—some urologists give 2-4 weeks while others give 2-3 months. We
seek to randomize patients to receive 2 weeks of antibiotics or 3 months of antibiotics after
surgery to remove all the kidney stones. We will see patients at 3, 6, and 12 months with
x-rays and to test their urine for bacterial infections. This is a multi-centre study with
participating 12 sites across North America.

Inclusion Criteria:

1. Male or Female.

2. No age restriction.

3. Diagnosed with an infection related stone.

4. Medically fit for definitive surgical management of stone.

5. Life expectancy greater than one year.

6. Stone free after definitive surgical therapy defined as fragments less than 3mm.

Exclusion Criteria:

1. Patients with medical comorbidities preventing them from definitive surgical therapy.

2. Patients with persistent stone burden following definitive surgical therapy.