Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 1/9/2019 |
| Start Date: | July 2015 |
| End Date: | March 9, 2018 |
This research is being done to find out how effective Prazosin is in the treatment of bulimic
patients experiencing distressing nightmares using subjective and objective measures.
patients experiencing distressing nightmares using subjective and objective measures.
To the investigators knowledge, there is no treatment trial for prazosin use in patients with
bulimia nervosa struggling with nightmares, looking at either objective or subjective
measures. The investigators plan to probe the effectiveness of prazosin in bulimic patients
experiencing nightmares due to PTSD using both subjective and objective measures in order to
improve future clinical care. The effects of prazosin on decreasing nightmares and bulimic
symptoms on subjective scales and effects on sleep architecture using objective polysomnogram
(PSG) measurements will help inform targeted psychopharmacologic and psychotherapeutic
strategies to improve clinical care of bulimic patients struggling with distressing dreams
secondary to PTSD. This study will be performed in two phases. Phase A will involve eight
participants who will be tested using subjective scales (mentioned below). If Phase A data
analysis leads to detection of a signal of efficacy 2 more participants will be recruited to
participate in phase B of this trial using objective polysomnogram measurements. The results
from this project will aid in establishing a fully powered clinical trial for treatment of
nightmares in bulimic patients and improve outcomes in this high risk population.
bulimia nervosa struggling with nightmares, looking at either objective or subjective
measures. The investigators plan to probe the effectiveness of prazosin in bulimic patients
experiencing nightmares due to PTSD using both subjective and objective measures in order to
improve future clinical care. The effects of prazosin on decreasing nightmares and bulimic
symptoms on subjective scales and effects on sleep architecture using objective polysomnogram
(PSG) measurements will help inform targeted psychopharmacologic and psychotherapeutic
strategies to improve clinical care of bulimic patients struggling with distressing dreams
secondary to PTSD. This study will be performed in two phases. Phase A will involve eight
participants who will be tested using subjective scales (mentioned below). If Phase A data
analysis leads to detection of a signal of efficacy 2 more participants will be recruited to
participate in phase B of this trial using objective polysomnogram measurements. The results
from this project will aid in establishing a fully powered clinical trial for treatment of
nightmares in bulimic patients and improve outcomes in this high risk population.
Inclusion Criteria:
- Age 18-45
- Clinical diagnosis of Bulimia Nervosa with complaint of nightmares secondary to PTSD
Exclusion Criteria:
- Restless leg syndrome
- Narcolepsy
- Sleep Apnea
- Neurological disorders
- Pregnancy
- cardiac abnormalities
- significant electrolyte abnormalities
- Use of steroids, beta blockers, prazosin
- Alcohol/substance abuse
We found this trial at
1
site
Hershey, Pennsylvania 17033
Phone: 717-531-8133
Click here to add this to my saved trials
