Inflammation in Type 2 Myocardial Infarction
| Status: | Withdrawn |
|---|---|
| Conditions: | Cardiology, Hospital |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2015 |
| End Date: | March 2016 |
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an
imbalance of myocardial oxygen supply and demand. Although type 2 MI is highly prevalent in
patients with critical illness and strongly associated with mortality, the pathophysiology
remains poorly understood. Inflammation is central to the development of atherosclerosis,
plaque rupture, and other subtypes of MI, but the role of inflammation in type 2 MI and
myocardial necrosis has not been defined. The investigators aim to to delineate the
mechanistic role of inflammation in myocardial necrosis and type 2 MI complicating critical
medical illness.
imbalance of myocardial oxygen supply and demand. Although type 2 MI is highly prevalent in
patients with critical illness and strongly associated with mortality, the pathophysiology
remains poorly understood. Inflammation is central to the development of atherosclerosis,
plaque rupture, and other subtypes of MI, but the role of inflammation in type 2 MI and
myocardial necrosis has not been defined. The investigators aim to to delineate the
mechanistic role of inflammation in myocardial necrosis and type 2 MI complicating critical
medical illness.
Inclusion Criteria:
- ≥21 years of age
- admitted to the Medical Intensive or Coronary Care Units
- sepsis or respiratory failure
- clinically indicated troponin measurement within 24 hours of ICU admission
Exclusion Criteria:
- unstable angina or Type 1 MI
- percutaneous or surgical coronary revascularization within 7 days
- heart failure exacerbation
- primary valvular disorder
- aortic dissection
- infiltrative heart disease or hypertrophic cardiomyopathy
- myocarditis
- pulmonary embolism
- electrocardiogram with >1mm ST segment elevation in two consecutive leads
- serum cardiac troponin >99th percentile URL but no clear rise or fall pattern
- history of chronic inflammatory disease
- use of therapeutic-dose anticoagulants / antiplatelet agents other than aspirin
- pregnant or incarcerated
- enrolled in a competing study
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