Identification of Genomic Changes in Families Having Multiple Members With Tumors

Genomic changes leading to the formation of brain tumors are slowly being discovered.
Despite advances in genomic technology, much analysis is hindered by the lack of control
samples that could better delineate genomic alterations leading to disease. The ideal
genomic control would be the genetic material of the parents of afflicted individuals. The
researchers propose to then compare the genomic material from parents of siblings, both of
whom have a diagnosis of a high-grade glioma. Additionally, the researchers will then
compare the genomic alterations between the parents and the patients. This analysis will
provide an unprecedented insight into genomic level changes that take place between parents
and patients that resulted in the formation of a high-grade glioma.

Inclusion Criteria:

- 18 years or older.

- Family history of brain tumor in first degree relative

Exclusion Criteria:

- less than 18 years