Remediation of Spatial Neglect Trial



Status:Completed
Conditions:Cognitive Studies, Neurology
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:6/10/2018
Start Date:July 2013
End Date:April 2017

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RESPONSE: Remediation of Spatial Neglect Trial

Problems with attention are a common and debilitating consequence of brain injury. Studies
show that poor attention is the number one predictor of poor cognitive functioning one year
post-injury. This is due to the fact that attention is a necessary component of more complex
cognitive functions such as learning & memory, multi-tasking and problem solving. In many
cases, individuals may exhibit problems with spatial attention known as 'hemi-spatial neglect
syndrome' or simply 'neglect'. Many studies now show that the processing machinery of the
brain is plastic and remodeled throughout life by learning and experience, enabling the
strengthening of cognitive skills or abilities. Research has shown that brief, daily
computerized cognitive training that is sufficiently challenging, goal-directed and adaptive
enables intact brain structures to restore balance in attention and compensate for
disruptions in cognitive functioning. The study aims to understand how our computer program
can affect cognition and attention in those with acquired brain injury.

Following consent, participants will engage in an assessment process to determine
eligibility. Once eligibility is confirmed, participants will be scheduled for another
assessment session to determine current level of cognitive function. This process consists of
paper-pencil surveys and computerized tests. Following the assessment process, participants
will engage in an Internet browser-delivered training sessions conducted on any
internet-accessible computer. The computerized training sessions can be done up to 7 times a
week (once a day) or at participant's convenience (we recommend 5 times a week). Following
the completion of training, the participant's cognitive function will be re-assessed.
Participation is voluntary and participants may withdraw from the study at any time.

Inclusion Criteria:

- 18 years of age or older

- A diagnosis of an acquired brain injury (which may be in the form of a stroke or brain
tumor removal) and

- Evidence of deficit on at least two assessment measures of Spatial Neglect

- Must be at least 3 months out from their most recent acquired brain injury, stroke, or
brain tumor removal

- Fluent English speakers

- Able to use a computer

- Adequate visual, auditory, and motor capacity to use computerized intervention

Exclusion Criteria:

- A history of conditions that could affect their thinking abilities (other that from
the brain injury), including mental illness, cancer, or other neurological conditions
(multiple sclerosis, seizure disorder), HIV/AIDS

- Concurrent enrollment in another study for acquired brain injury or otherwise.

- A current or significant past history of substance abuse

- Severe depression or other chronic psychiatric disorders with cognitive impairments,
eg. Schizophrenia
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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