Novel Biomarkers for Risk Prediction of Contrast-Induced Acute Kidney Injury Post Coronary Angiography
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Renal Impairment / Chronic Kidney Disease, Hospital |
| Therapuetic Areas: | Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/19/2018 |
| Start Date: | January 2015 |
| End Date: | December 2016 |
Novel Biomarkers for Risk Prediction of Contrast-Induced Acute Kidney Injury Post Coronary Angiography (NORDICA Study)
Contrast-induced acute kidney injury (CI-AKI) has been recognized as the third most common
cause of hospital acquired AKI, after hypotension-associated hypo-perfusion and
post-operative AKI. The development of CI-AKI after cardiac catheterization is associated
with a significant increase in both short-term and long-term mortality and morbidities, as
well as an increase in length of stay and cost.
The only marker of renal function that has predictive ability is creatinine and it has
significant limitations in identifying patients who will develop AKI. Therefore, a diagnostic
test for predicting CI-AKI risk would have widespread clinical utility.
The primary purpose of this study is to measure the association between baseline expression
of senescence markers in blood using SenesceTest and the occurrence of CI-AKI post cardiac
catheterization.
cause of hospital acquired AKI, after hypotension-associated hypo-perfusion and
post-operative AKI. The development of CI-AKI after cardiac catheterization is associated
with a significant increase in both short-term and long-term mortality and morbidities, as
well as an increase in length of stay and cost.
The only marker of renal function that has predictive ability is creatinine and it has
significant limitations in identifying patients who will develop AKI. Therefore, a diagnostic
test for predicting CI-AKI risk would have widespread clinical utility.
The primary purpose of this study is to measure the association between baseline expression
of senescence markers in blood using SenesceTest and the occurrence of CI-AKI post cardiac
catheterization.
Inclusion Criteria:
- Adult patients (>18 yo) undergoing invasive coronary angiography with or without
percutaneous coronary intervention (PCI), that are predicted to have ≥14% risk of
developing AKI as defined by Mehran et al.
- Medically compliant and able to consent and follow detailed directions
- Agree to additional collection of blood sample 48-72h post cardiac catheterization
Exclusion Criteria:
- Presence of acute, active infection (e.g. HIV, pneumonia, septic shock).
- Contrast media exposure within last 48h
- Presenting with systolic time-segment elevation myocardial infarction.
- Presence of cardiogenic shock
- Presence of hemodynamic instability or requiring pressors or intra-aortic balloon pump
- Severe kidney disease with estimated glomerular filtration rate <30 mL/min/1.73m2 or
receiving dialysis for end stage renal disease
- Kidney transplant and liver transplant patients and all patients currently on
immunosuppressants
- Severe heart failure with known ejection fraction <25%
- Prior heart transplant
- Chronic liver disease /cirrhosis
- Patients actively undergoing chemotherapy or radiation treatment for any indication.
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