Pharmacokinetics of GS-9857 in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

Inclusion Criteria:

- All individuals:

- Screening laboratory values within defined thresholds for group

- Use of two effective contraception methods if female of childbearing potential
or sexually active male

- For individuals with moderate hepatic impairment:

- Diagnosis of chronic (> 6 months) hepatic impairment

- Score on the Child-Pugh-Turcotte (CPT) scale of 7-9 at screening (Child Pugh
Class B).

- For individuals with severe hepatic impairment:

- Diagnosis of chronic (> 6 months) hepatic impairment

- Score on the CPT scale of 10-15 at screening (Child Pugh Class C)

- For individuals with normal hepatic function:

- Hepatitis C Virus (HCV) antibody and hepatitis B surface antigen negative

Exclusion Criteria:

- All individuals:

- Pregnant or nursing female or male with pregnant female partner

- HIV infection

- History of clinically significant illness or any other medical disorder that may
interfere with the individual's treatment, assessment or compliance with the
protocol

- For individuals with moderate or severe hepatic impairment:

- Active HCV infection

- Current hepatic encephalopathy

- Variceal bleeding in the last 6 months unless banded

- Prior placement of a portosystemic shunt

- History of hepatorenal or hepatopulmonary syndrome

- Spontaneous bacterial peritonitis currently or within the last 6 months

- Hospitalization within the last 2 months related to cirrhosis

- Confirmed hypotension

- Suspicion of hepatocellular carcinoma