Targeting Cognition in Bipolar Disorder With Pramipexole

All eligible participants will undergo study visits at screening, baseline (week 0), week 1,
week 2, week 3, week 4, week 6, week 8, and week 12, (end of study).

Randomization will be conducted via a computer generated program and all study staff will be
blinded unless un-blinding is required for safety reasons. Subjects will be randomized on a
1:1 ratio with stratification for concomitant antipsychotic status and depression at baseline
(HRSD <8 vs > 8). Study drug will be blinded and matched to placebo. Adapting from our
previous work in BD and according to package labeling, the dosage titration schedule will be
slow and flexible. Dosing will be initiated at 0.25 mg QHS on night one, followed by 0.25 mg
BID day two onward, and increased every week to a target of 4.5 mg/day. As compared with our
previous maximum 1.5 mg/day (Burdick et al. 2012), we opted to allow up to 4.5 mg/day (the
maximum approved dosage in Parkinson's disease) to ensure adequate target engagement. We are
familiar with this dose range, as 4.5 mg/day was allowed in our study in BD depression
(Goldberg et al. 2004). Dosing will be flexible based on side effects; however, if 1.5 mg/day
cannot be tolerated, the subject will be discontinued. Titration will occur up to week 6 and
then efforts will be made to maintain the same dose until the completion of the trial (week
12).

Inclusion criteria:

- Age 18-65

- DSM-IV BD I or II diagnosis

- Affective stability, defined by a Young Mania Rating Scale (YMRS) rating of < 8 and a
Hamilton Depression Rating Scale (HRSD) rating of < 16 at screening and baseline. We
will further require that any subsyndromal depression has not significantly worsened
in the 4 weeks prior to randomization so as to avoid enrolling subjects who are on the
verge of a full depressive episode.

- Evidence of clinically-significant neurocognitive impairment at screening

- Clinically-acceptable, stably-dosed, mood stabilizing medication regimen for > 1 month
prior to enrollment, with no medication changes planned over the 12-week study period.

Exclusion Criteria:

- History of CNS trauma, neurological disorder, ADHD, or learning disability

- Positive urine toxicology or DSM-IV diagnosis of substance abuse/dependence within 3
months

- Active, unstable medical problem that may interfere with cognition

- Recent history of rapid-cycling

- Abnormal lab or ECG result at screen

- History of heart failure

- Significant suicidal risk (HRSD item 3 > 2 or by clinical judgment)

- Estimated IQ in MR range as per Wide Range Achievement Test (WRAT) standard score of
less than 70

- Pregnant women or women of child bearing potential who are not using a medically
accepted means of contraception (including oral contraceptive or implant, condom,
diaphragm, spermicide, intrauterine device, tubal ligation, or partner with vasectomy)

- Women who are breastfeeding

- Participation in any other investigational cognitive enhancement study within 30 days