Destiffening and Hypotensive Effects of Whole Milk and Full-fat Dairy Products
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 20 - 80 |
| Updated: | 2/3/2018 |
| Start Date: | March 2015 |
| End Date: | January 30, 2018 |
The specific aim of the proposed study is to address the efficacy of conventional full-fat
dairy products as part of the normal routine diet for improving vascular function and
reducing blood pressure in middle-aged and older adults with elevated blood pressure. The
investigators hypothesize that dietary intervention including whole milk and full-fat milk
products will induce significant decreases in systolic blood pressure and arterial stiffness.
The investigators also test the hypothesis that the reductions in blood pressure will be
associated with the corresponding decreases in arterial stiffness and/or increases in
endothelial vasodilatory function as well as improvements in arterial baroreflex sensitivity.
If our hypotheses are supported by the results, the information could be used as a basis for
recommendations for the use of whole milk and full-fat milk products in the secondary
prevention of elevated blood pressure and vascular dysfunction.
dairy products as part of the normal routine diet for improving vascular function and
reducing blood pressure in middle-aged and older adults with elevated blood pressure. The
investigators hypothesize that dietary intervention including whole milk and full-fat milk
products will induce significant decreases in systolic blood pressure and arterial stiffness.
The investigators also test the hypothesis that the reductions in blood pressure will be
associated with the corresponding decreases in arterial stiffness and/or increases in
endothelial vasodilatory function as well as improvements in arterial baroreflex sensitivity.
If our hypotheses are supported by the results, the information could be used as a basis for
recommendations for the use of whole milk and full-fat milk products in the secondary
prevention of elevated blood pressure and vascular dysfunction.
Inclusion Criteria:
- Prehypertension or stage-1 hypertension
Exclusion Criteria:
- Consume > 3 servings of dairy or fruit per day
- Strenuous physical activity > 3 time per week
- Lactose intolerance, pregnancy, lactation, and/or alcohol abuse
- Taking cardiovascular-acting drugs
- Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease
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