A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer



Status:Completed
Conditions:Cancer, Cancer, Pancreatic Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:9/20/2018
Start Date:May 2015
End Date:August 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Placebo-controlled Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine Versus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer

The purpose of this study is to determine whether the combination of MM-141 plus
nab-paclitaxel and gemcitabine is more effective than nab-paclitaxel and gemcitabine alone
based on Progression Free Survival (PFS) in front-line metastatic pancreatic cancer patients
with high serum levels of free IGF-1.

This is a randomized, double-blind, placebo-controlled Phase 2 study of MM-141 plus
nab-paclitaxel and gemcitabine or placebo plus nab-paclitaxel and gemcitabine in front-line
metastatic pancreatic cancer. All patients will be initially screened for free IGF-1 status.
Eligible patients with high free IGF-1 will be randomized to receive MM-141 plus
nab-paclitaxel and gemcitabine or placebo plus nab-paclitaxel and gemcitabine and patients.
Patients with low free IGF-1 or patients who have high free IGF-1 but are not otherwise
eligible will be followed in an observational group.

Inclusion Criteria:

- Metastatic adenocarcinoma of the pancreas. Patients with islet cell neoplasms are not
eligible.

- Patient must have received no prior radiotherapy, surgery, chemotherapy, or
investigational therapy for the treatment of metastatic disease.

- Blood sample sent for free IGF-1 testing

- ECOG performance status (PS) of 0 or 1

Exclusion Criteria:

- Patients who only present with localized disease

- Patients with CNS malignancies (primary or metastatic)

- Clinically significant cardiac disease
We found this trial at
48
sites
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
Principal Investigator: Crystal Denlinger, MD
Phone: 215-214-1685
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Vanderbilt-Ingram Cancer Center
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Principal Investigator: Emily Chan, MD
Phone: 615-875-0060
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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Columbia University
116th St and Broadway
New York, New York 10027
(212) 854-1754
Principal Investigator: Paul Oberstein, MD
Phone: 212-342-0248
Columbia University In 1897, the university moved from Forty-ninth Street and Madison Avenue, where it...
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New York Oncology HematologyPC
Albany, New York
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Pacific Cancer Medical Center
Anaheim, California 92801
Principal Investigator: Veena Charu, MD
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Rocky Mountain Cancer Centers
Aurora, Colorado 80012
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Texas Oncology - Austin Midtown
Austin, Texas 78705
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Austin, TX
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Texas Oncology P A Bedford
Bedford, Texas
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St. Luke's University Health Network
Bethlehem, Pennsylvania
Principal Investigator: Asim Ali, MD
Phone: 484-526-3589
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Bethlehem, PA
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Roswell Park Cancer Inst
Buffalo, New York 14263
Principal Investigator: Wen Wee Ma, MD
Phone: 716-845-8309
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Buffalo, NY
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Northwestern University
303 East Superior Street
Chicago, Illinois 60611
Principal Investigator: Halla Nimeiri, MD
Phone: 312-695-1102
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Chicago, IL
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University of Illinois at Chicago
2035 W Taylor St
Chicago, Illinois
(312) 996-4350
Principal Investigator: Arkadiusz Dudek, MD
Phone: 312-413-1902
University of Illinois at Chicago A major research university in the heart of one of...
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Illinois Cancer Specialists
Chicago, Illinois 60611
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Mid Ohio Onco/ Zangmeister Ctr
3100 Plaza Properties Boulevard
Columbus, Ohio 43219
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Columbus, OH
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Bassett Cancer Institute
1 Atwell Road
Cooperstown, New York 13326
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Cooperstown, NY
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Texas Oncology-Dallas P.H.
8196 Walnut Hill Lane
Dallas, Texas 75231
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North Shore Hematology Oncology Associates
East Setauket, New York 11733
Principal Investigator: David Chu, MD
Phone: 631-675-5143
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Cross Cancer Institute
Edmonton, Alberta
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Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Brooke Army Medical Center (BAMC)
Fort Sam Houston, Texas 78234
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St. Jude Heritage Healthcare
Fullerton, California 92835
Principal Investigator: David Park, MD
Phone: 714-446-5364
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Fullerton, CA
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Banner MD Anderson Cancer Center
Gilbert, Arizona 85234
Principal Investigator: Madappa N. Kundranda, MD
Phone: 480-256-4649
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Gilbert, AZ
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Compr Cancer Centers of Nevada
10001 South Eastern Avenue
Henderson, Nevada 89052
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Henderson, NV
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Cancer Center of Acadiana Research Department
Lafayette, Louisiana 70503
Principal Investigator: Salman Malad, MD
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Lafayette, LA
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UCLA School of Medicine
Los Angeles, California
Principal Investigator: Randolph Hecht, MD
Phone: 310-633-8400
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Baptist Health Med Gr Onc, LLC
14701 Northwest 77th Avenue
Miami, Florida 33014
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SCRI - Tennessee Oncology
Nashville, Tennessee 37203
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Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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Cancer Treatment Centers of America-Georgia
Newnan, Georgia 30265
Principal Investigator: Eyal Meiri, MD
Phone: 770-400-7191
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Newnan, GA
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Florida Cancer AffiliatesOcala
433 Southwest 10th Street
Ocala, Florida 34471
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Ocala, FL
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Texas Oncology-Paris
Paris, Texas 75460
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Paris, TX
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Oncology Specialists, SC
Park Ridge, Illinois 60068
Principal Investigator: Edward James, MD
Phone: 847-410-0667
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Park Ridge, IL
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Memorial Regional Hospital
Pembroke Pines, Florida 33028
Principal Investigator: Pablo Ferraro, MD
Phone: 954-265-1864
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Allegheny Cancer Center
Pittsburgh, Pennsylvania 15212
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Texas Oncology-Plano East
Plano, Texas 75075
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Cancer Care Assoc Med Grp
Redondo Beach, California 90277
Principal Investigator: Hugo Hool, MD
Phone: 310-750-3376
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Onc and Hem Asso of SW VA Inc
1802 Braeburn Drive
Salem, Virginia 24153
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Texas Oncology SA Medical Ctr
5206 Research Drive
San Antonio, Texas 78240
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UCSF Cancer Center
San Francisco, California 94115
Principal Investigator: Andrew Ko, MD
Phone: 415-353-7284
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Sansum Clinic
Santa Barbara, California 93105
Principal Investigator: Gregg Newman, MD
Phone: 805-898-3602
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Central Coast Med Onc Corp
Santa Maria, California 93454
Principal Investigator: Robert Dichmann, MD
Phone: 805-346-3461
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Santa Maria, CA
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Nylen Cancer Center
230 Nebraska Street
Sioux City, Iowa 51101
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Sioux City, IA
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Cancer Care Northwest, P.S.
Spokane Valley, Washington 99216
Principal Investigator: Danko Martincic, MD
Phone: 509-228-1188
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Tulsa Cancer Institute, Pllc
12697 E 51st Street South
Tulsa, Oklahoma 74146
918-505-3200
Tulsa Cancer Institute, Pllc Now under the new name of Tulsa Cancer Institute, our specialists...
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Texas Oncology-Tyler
Tyler, Texas 75702
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Northwest Cancer SpecialistsPC
2501 Northeast 134th Street
Vancouver, Washington 98686
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Reliant Medical Group
Worcester, Massachusetts 01608
Principal Investigator: James Rooney, MD
Phone: 508-556-5431
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Worcester, MA
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Midwest Regional Medical Cntr
2520 Elisha Avenue
Zion, Illinois 60099
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