The Role of Emotional Arousal in Food Preference and Taste
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 1/14/2018 |
| Start Date: | August 2013 |
| End Date: | August 2019 |
| Contact: | Rajita Sinha, PhD |
| Email: | Rajita.sinha@yale.edu |
| Phone: | 203-737-5805 |
The Purpose of This Study is to Investigate the Role of Stress in Food Craving and Food Consumption by Examining Stress Response Using Subjective, Physiological and Neurobiological Measurements
The purpose of this study is to examine the role of stress in food craving and food
consumption in obesity. Using experimentally validated guided imagery procedure, the
investigators propose to examine the stress response using subjective, physiological and
neurobiological measurements.
consumption in obesity. Using experimentally validated guided imagery procedure, the
investigators propose to examine the stress response using subjective, physiological and
neurobiological measurements.
One hundred and fifty men and women will participate in three laboratory sessions to assess
stress responses to personal stress imagery, food cue imagery, and to neutral-relaxing
imagery. Subjects will be distributed into 3 groups stratified by BMI category. Subject
recruitment, eligibility determination, baseline assessments and script development will be
conducted at the Yale Stress Center. Subjects will complete a variety of diagnostic,
cognitive and psychological assessments, a comprehensive physical examination and blood work
and will be involved in development of imagery scripts from personal stress, food cue and
neutral-relaxing situations. Subjects will then be scheduled for three laboratory sessions at
the Yale Stress Center. Subjects will also participate in an imagery and relaxation training
session followed by three laboratory sessions. The three laboratory sessions will be
conducted within a brief interval of days, when subjects will be exposed to a personal
stress, a food cue and a neutral-relaxing imagery condition, one condition per day. The order
of imagery conditions will be randomly assigned and counterbalanced across subjects in order
to balance any influences due to order of imagery conditions.
stress responses to personal stress imagery, food cue imagery, and to neutral-relaxing
imagery. Subjects will be distributed into 3 groups stratified by BMI category. Subject
recruitment, eligibility determination, baseline assessments and script development will be
conducted at the Yale Stress Center. Subjects will complete a variety of diagnostic,
cognitive and psychological assessments, a comprehensive physical examination and blood work
and will be involved in development of imagery scripts from personal stress, food cue and
neutral-relaxing situations. Subjects will then be scheduled for three laboratory sessions at
the Yale Stress Center. Subjects will also participate in an imagery and relaxation training
session followed by three laboratory sessions. The three laboratory sessions will be
conducted within a brief interval of days, when subjects will be exposed to a personal
stress, a food cue and a neutral-relaxing imagery condition, one condition per day. The order
of imagery conditions will be randomly assigned and counterbalanced across subjects in order
to balance any influences due to order of imagery conditions.
Inclusion Criteria:
- Between ages 18-45 years
- Able to read and write
- Normal/lean BMI group: BMI 18.5-24.9 as calculated based on height and weight.
- Overweight BMI group: BMI 25.0 - 29.9 as calculated based on height and weight Obese
BMI group: BMI 30-35 as calculated based on height and weight.
- Do not meet criteria for any current Axis I DSM-IV psychiatric diagnoses and provide
negative urine toxicology screens during initial appointments and at admission for
laboratory sessions.
Exclusion Criteria:
- Meet current criteria for dependence on any psychoactive substance, including nicotine
and caffeine
- Current use of any psychoactive drugs, including anxiolytics, antidepressants,
naltrexone or antabuse
- Any psychotic disorder or current psychiatric symptoms requiring specific attention,
including need for psychiatric medications for current major depression and anxiety
disorders
- Any significant current medical condition such as neurological, cardiovascular,
endocrine, renal, liver, thyroid pathology; subjects on medications for any medical
condition will be excluded
- Women on oral contraceptives, peri and post menopausal women, and those with
hysterectomies
- Pregnant and lactating women will be excluded.
We found this trial at
1
site
New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: Rajita Sinha, PhD
Phone: 203-737-4791
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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