Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I

Inclusion Criteria:

- Informed consent signed.

- Male or female participant between 18 years and 80 years of age.

- A diagnosis of complex regional pain syndrome type I according to the clinical
diagnostic criteria using the International Association for the Study of Pain clinical
diagnostic criteria (Budapest criteria).

- Baseline Pain Intensity Score of 4 or greater using an 11-point Numerical Rating Scale
referring to the CRPS-affected limb.

- In stable treatment and follow-up therapy for CRPS type I for at least 1 month.

- Participant has undergone a recent regular dental examination.

- Women of child-bearing potential must have a negative urine ß-HCG pregnancy test at
enrollment.

- Women of child-bearing potential must practice protocol defined acceptable methods of
birth control during the trial.

- Participants must be able to communicate meaningfully, be able to differentiate with
regard to location and intensity of the pain, and be able to answer the questions in
the questionnaires used in this trial.

- Compliance with the use of electronic diary assessed prior to allocation to treatment.

Exclusion Criteria:

- A diagnosis of complex regional pain syndrome type II.

- Documented history or diagnosis of peripheral neuropathy, including diabetic
peripheral neuropathy or other metabolic or toxic neuropathy, or any other chronic
pain condition that would significantly affect a participant's ability to report
CRPS-related pain.

- Body weight less than 40 kg.

- Evidence of renal impairment or a history of chronic kidney disease.

- Serum calcium or magnesium outside of the central laboratory's reference range;
history of hypocalcemia; any metabolic disorder anticipated to increase risk for
hypocalcemia.

- Vitamin D deficiency. Participants with vitamin D deficiency prior to enrollment may
be enrolled with appropriate supplementation during the enrollment period.

- Corrected QT interval greater than 470 milliseconds; treatment with medications within
the last 30 days prior to allocation to IMP that have potential to prolong the QT
interval or anticipated need for such medications during the course of the trial.

- Any prior use of a bisphosphonate for treatment of CRPS, any prior administration of
intravenous bisphosphonate, administration of oral bisphosphonate within the previous
year, anticipated requirement for treatment with oral or intravenous bisphosphonate
for another condition such as osteoporosis during the trial, or administration of
denosumab (Prolia) or other bone turnover suppressing drugs within the past 6 months.

- History of any allergic or hypersensitivity reaction to neridronic acid or other
bisphosphonate, or to vitamin D or calcium supplements.

- Recent tooth extraction, unhealed or infected extraction site, or significant
dental/periodontal disease that may pre-dispose to need for tooth extraction or other
invasive dental procedures during the trial.

- Evidence of denture-related gum trauma or improperly fitting dentures causing injury.

- Prior radiation therapy of the head or neck (within 1 year of enrollment).

- Recent treatment with high doses of systemic steroids or anticipated need for
concomitant high-dose steroid treatment during the trial.

- History of malignancy within 2 years before enrollment with the exception of basal
cell carcinoma.

- Daily intake of long- and short-acting or controlled-release opioid analgesics of more
than 200 mg morphine equivalents, regimens combining high-dose opioids and
benzodiazepines, or any other treatment regimen considered unstable, unsafe, or have
potential to affect the interpretation of the trial.

- Use of nerve blocks, ketamine infusions, intravenous immunoglobulin, acupuncture,
electromagnetic field treatment, or initiation/implementation of radiofrequency
ablation or other sympathectomy procedures, or peripheral nerve stimulation within 6
weeks prior to allocation to investigational medicinal product.

- Evidence of current alcohol or drug abuse, or history of alcohol or drug abuse within
2 years of enrollment, based on participant history and physical examination and
according to the investigator's judgment.

- Any other severe medical condition, including severe depression, or any other severe
mood disorder, that in the opinion of the investigator may affect efficacy or safety
assessments or may compromise the participant's safety during trial participation.

- Participant is engaged in litigation related to their disability from CRPS in which
monetary gain or loss (or other compensation) may affect their objective participation
in the trial.

- Women who are pregnant or breastfeeding.

- Elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater
than 2-fold upper limit of normal (ULN), or evidence or history of liver disease.

- Participation in an investigational drug trial within 3 months prior to enrollment, or
prior participation in this trial with receipt of any infusion of IMP, even a partial
infusion.