Meloxicam SoluMatrix® Capsules vs Meloxicam Tablets to Treat Osteoarthritis Pain

Inclusion Criteria:

- Primary diagnosis of Functional Class I-III osteoarthritis (OA) of the hip or knee

- Chronic user of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or acetaminophen
for OA pain

- Discontinued all analgesic therapy at Screening

- For women of childbearing potential: a woman who is not pregnant and not nursing,
and who is practicing an acceptable method of birth control

- Ability to ambulate

Exclusion Criteria:

- History of allergic reaction or clinically significant intolerance to acetaminophen,
aspirin, or any NSAIDs, including meloxicam

- Requires regular (more than 2 doses per week) use of opioid or opioid combination
products to control OA pain of the knee or hip

- Clinically significant unstable cardiac, respiratory, neurological, immunological,
hematological, or renal disease

- Significant difficulties swallowing capsules/tablets or unable to tolerate oral
medication

- Previous participation in another clinical study of Meloxicam Capsules or received
any investigational drug or device or investigational therapy within 30 days before
Screening