A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis



Status:Completed
Conditions:Ocular, Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:18 - 85
Updated:3/14/2019
Start Date:March 2015
End Date:April 2016

Use our guide to learn which trials are right for you!

A Phase 2 Randomized, Investigator-Masked, Comparator-controlled Trial to Evaluate the Safety and Efficacy of NS2 Eye Drops in Patients With Anterior Uveitis

This is a randomized, multi-center, investigator masked, comparator controlled study. The
purpose of this study is to determine the efficacy and safety of NS2 in patients with
non-infectious acute anterior uveitis. Subjects will be randomized 1:1:1 to receive multiple
doses of NS2 0.5%, NS2 0.5% and Pred Forte® 1%, or Pred Forte® 1%.

Free aldehydes are thought to be related to inflammatory diseases such as uveitis. NS2, a
small molecule aldehyde trap, may decrease inflammation by lowering aldehyde levels.


Inclusion Criteria:

- Non-infectious anterior uveitis

- Grade 1 - Grade 3 anterior chamber cell count

- Subjects must have Intraocular pressure <25 mmHg at baseline and may only administer a
maximum of 1 topical medication to control Intraocular pressure in the study eye.

- Visual acuity ≥ 20/200 in the study eye

Exclusion Criteria:

- Severe/serious ocular pathology

- Active intermediate or posterior uveitis.

- Previous anterior uveitis episode in the study eye within 4 weeks of Visit 1

- Oral corticosteroids within 14 days of Visit 1

- Intravitreal or sub-Tenon corticosteroid treatment in the study eye within the past 6
months.
We found this trial at
15
sites
Ayer, Massachusetts 01940
2455
mi
from 98109
Ayer, MA
Click here to add this to my saved trials
Birmingham, Michigan 48009
1919
mi
from 98109
Birmingham, MI
Click here to add this to my saved trials
Boston, Massachusetts 02114
2485
mi
from 98109
Boston, MA
Click here to add this to my saved trials
Chesterfield, Missouri 63017
1703
mi
from 98109
Chesterfield, MO
Click here to add this to my saved trials
Golden, Colorado 80401
1010
mi
from 98109
Golden, CO
Click here to add this to my saved trials
Hamden, Connecticut 06518
2431
mi
from 98109
Hamden, CT
Click here to add this to my saved trials
Houston, Texas 77025
1891
mi
from 98109
Houston, TX
Click here to add this to my saved trials
Kansas City, Missouri 64111
1504
mi
from 98109
Kansas City, MO
Click here to add this to my saved trials
Lancaster, California 93534
919
mi
from 98109
Lancaster, CA
Click here to add this to my saved trials
Norfolk, Virginia 23502
2434
mi
from 98109
Norfolk, VA
Click here to add this to my saved trials
Omaha, Nebraska 68106
1367
mi
from 98109
Omaha, NE
Click here to add this to my saved trials
Palisades Park, New Jersey 07650
2398
mi
from 98109
Palisades Park, NJ
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19107
2373
mi
from 98109
Philadelphia, PA
Click here to add this to my saved trials
Plantation, Florida 33324
2712
mi
from 98109
Plantation, FL
Click here to add this to my saved trials
2476
mi
from 98109
Waltham, MA
Click here to add this to my saved trials