Neurophysiological Attention Test (NAT) for Objective Assessment of Attention Deficit Hyperactivity Disorder (ADHD)

The purpose of this study is to develop a novel approach and software for analyzing
electroencephalography (EEG) data to identify biomarkers of ADHD. Then to test the ability
of this assessment tool to differentiate between adults with ADHD and healthy controls by
comparing the classification accuracy of the metrics from the new tool to the classification
accuracy of existing behavioral tests for ADHD.

Inclusion Criteria:

- Specific inclusion criteria for ADHD are:

1. meet established DSM-5 criteria for ADHD predominately inattentive or combined
subtype with clinically significant levels of impairment, diagnosed by
structured clinical interview, the Mini International Neuropsychiatric
Interview, and corroborating information

2. Clinical Global Impression—Severity (CGI-S) score ≥ 4 for ADHD

3. no lifetime history of DSM-5 bipolar disorder, psychotic disorder, pervasive
developmental disorder, obsessive-compulsive disorder, substance abuse, or
substance dependence (except nicotine) as assessed wit the MINI

4. able in the opinion of the investigator to complete all required study
procedures.

Exclusion Criteria:

- Exclusion criteria for both groups are:

1. History of diagnosis of childhood disorder other than ADHD (e.g. autism,
dyslexia)

2. history of any general medical condition likely to require chronic use of
medication with identified CNS effects suspected to alter cognitive performance

3. history of seizure disorder, brain tumor, other major neurological disorder or
head injury resulting in loss of consciousness

4. serious oxygen deprivation

5. current psychopathology requiring ongoing treatment with antipsychotic
medications, mood stabilizers, benzodiazepines, or anticonvulsants

6. current untreated psychopathology which is rated to be primary in terms of
severity (greater than ADHD severity)

7. current treatment with guanfacine.