Comparison of Patient Centered Outcomes for People With SCD in the Acute Care Setting

Emergency Department care is marked by long delays, lack of efficacy, and conflict. A
sub-specialty Infusion Center staffed by expert clinicians and delivering individualized care
can improve care quality while reducing costs. The study will examine whether care provided
in an Infusion Center is more patient centered and efficient than care provided in an
Emergency Department for adults with SCD and uncomplicated VOC.

Sites will prospectively enroll patients in VOC seen in participating centers from either the
EDs or the ICs. Specific data from the acute visits (e.g. Times of arrival, time to first
dose of analgesic, etc) will be captured. This study will compare: pain management,
disposition of subjects (home or admission) and patient experiences of care delivery in both
settings. Subjects will complete surveys/questionnaires to asses their experiences in the
setting where care was provided.

The four sites to participate in the study are Baltimore, Maryland (Johns Hopkins Hospital),
Cleveland, Ohio (Cleveland Medical Center), Milwaukee, Wisconsin (Medical College of
Wisconsin), and Baton Rouge, Louisiana (Our Lady of the Lake Hospital). A maximum of 500
subjects will participate in the study. Participants will be enrolled for 18 months.

Inclusion Criteria:

- Confirmed Sickle Cell Disease patients who live within 60 miles of the study center or
who already receive regular care at the participating centers.

Exclusion Criteria:

- Stable patients who have been on chronic transfusion therapy and have not had a
painful episode within two years of enrollment.

- Patients who are pregnant.

- Patients who are unwilling or unable to sign consent.