Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism



Status:Completed
Conditions:Cognitive Studies, Obesity Weight Loss, Endocrine, Endocrine
Therapuetic Areas:Endocrinology, Psychiatry / Psychology
Healthy:No
Age Range:6 - 18
Updated:6/10/2018
Start Date:December 2014
End Date:January 2017

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Trial Summary
Trial Overview
Inclusion Criteria
Pseudohypoparathyroidism type 1a (PHP1a) is a rare disease that causes childhood obesity and
learning difficulties. This study will investigate eating behaviors and perform cognitive
testing on children with PHP1a. The investigators will compare their results to those of
healthy siblings and other obese children.

Pseudohypoparathyroidism type 1a (PHP1a) is a genetic disorder that causes early-onset,
syndromic obesity and cognitive impairment. This study aims to evaluate eating behaviors,
cognition and executive function in children with PHP1a, compared with healthy siblings and
matched obese controls.

Inclusion Criteria:

- Clinical diagnosis of PHP1a, sibling of a patient with PHP1a or matched obese control

Exclusion Criteria (PHP1a):

- Treatment with appetite-altering drug or initiation of a new weight loss program in
the past 3 months

- Type 2 diabetes

Exclusion Criteria (Controls):

- Obesity due to a genetic syndrome, growth hormone deficiency, untreated
hypothyroidism, Cushing syndrome or exogenous glucocorticoid administration

- Weight loss greater than 10% over the previous 6 months

- Autism or other significant learning disorder

- Type 2 diabetes

- Other significant medical condition
We found this trial at
1
site
Vanderbilt University
2201 West End Ave
Nashville, Tennessee 37232
(615) 322-7311
Vanderbilt University Vanderbilt offers undergraduate programs in the liberal arts and sciences, engineering, music, education...
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mi
from
Nashville, TN
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