Genetic Profiling of Liver Cancer in Patients Undergoing Liver Transplantation
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Liver Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 7/19/2017 |
| Start Date: | March 2015 |
| End Date: | December 2017 |
Circulating MicroRNA Isoforms as Biomarkers in Hepatocellular Carcinoma and Associated Liver Transplantation
The purpose of this study is to determine whether genetic markers unique to liver cancer are
present and to assess usefulness as a diagnostic tool.
present and to assess usefulness as a diagnostic tool.
Hepatocellular carcinoma (HCC) is the most common form of liver cancer and a growing trend
worldwide. Decision-making regarding treatment for patients is limited by the lack of
clinically actionable biomarkers. This is pronounced in the case for determining and
monitoring liver transplant recipients. In an effort to improve diagnosis, the use of
circulating serum-based microRNA isoforms (isomiRs) can serve as non-invasive, screening
biomarkers in HCC patients pre- and post-transplantation of the liver.
worldwide. Decision-making regarding treatment for patients is limited by the lack of
clinically actionable biomarkers. This is pronounced in the case for determining and
monitoring liver transplant recipients. In an effort to improve diagnosis, the use of
circulating serum-based microRNA isoforms (isomiRs) can serve as non-invasive, screening
biomarkers in HCC patients pre- and post-transplantation of the liver.
Inclusion Criteria:
- Patients with the diagnosis of HCC who are on the wait list for liver transplantation
- Patients with the diagnosis of HCC who have been admitted to hospital, scheduled to
undergo liver transplantation within the following 24 hours.
- Age Range: 18 to 75 years old
Exclusion Criteria:
- Patients with metastatic HCC and patients with the diagnosis of HCC who are not on the
wait list for liver transplantation.
- Patients older than 75 years old and younger than 18 years old.
- Patients who are unable to consent.
- Pregnant patients.
We found this trial at
1
site
3500 Gaston Avenue
Dallas, Texas 75246
Dallas, Texas 75246
1.800.422.9567
Principal Investigator: Peter Kim, M.D.
Phone: 214-820-1710
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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