F 18 T807 Tau PET Imaging of Alzheimer's Disease
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Alzheimer Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/26/2019 |
| Start Date: | October 2014 |
| End Date: | December 2019 |
F 18 T807 Tau PET Imaging of Alzheimer's Disease [IND# 123119] Protocol A
This project will collect quantitative pilot data that will allow the characterization of
uptake and binding of 18F-AV-1451 (also known as F 18 T807), a novel tau imaging compound, in
individuals with and without brain tau fibrils. The primary goal is to develop tau imaging
technique as an antecedent biomarker of cognitive decline. The investigators propose to
obtain preliminary data that will support the possibility of detecting cognitive decline in
its earliest stages, before the occurrence of dementia.
uptake and binding of 18F-AV-1451 (also known as F 18 T807), a novel tau imaging compound, in
individuals with and without brain tau fibrils. The primary goal is to develop tau imaging
technique as an antecedent biomarker of cognitive decline. The investigators propose to
obtain preliminary data that will support the possibility of detecting cognitive decline in
its earliest stages, before the occurrence of dementia.
Inclusion Criteria:
1. Male or female participants, at least 18 years of age.
2. Cognitively normal, or with mild dementia, as assessed clinically
3. Participant is able and willing to undergo testing (MRI or CT, PET, radioactive tracer
injection, LP; for those unable to undergo an MRI, CT will be used to generate
regions-of-interest).
4. Pre-menopausal women will undergo a urine pregnancy test within 24 hours of drug
administration.
Exclusion Criteria:
1. Has any condition that, in the Investigator's opinion, could increase risk to the
participant, limit the participant's ability to tolerate the experimental procedures,
or interfere with the collection/analysis of the data (for example, participants with
severe chronic back pain might not be able to lie still during the scanning
procedures).
2. Is deemed likely unable to perform the imaging procedures for any reason.
3. Has a high risk for Torsades de Pointes or is taking medications known to prolong QT
interval.
4. Has hypersensitivity to F 18 T807 or any of its excipients.
5. Contraindications to PET, PET-CT or MR (e.g. electronic medical devices, inability to
lie still for long periods) that make it unsafe for the individual to participate.
6. Severe claustrophobia.
7. Currently pregnant or breast-feeding.
8. For those electing to undergo the optional lumbar puncture: currently on anticoagulant
of any form -
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Phone: 314-362-6737
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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