Studying Genes in Samples From Younger Patients With Acute Megakaryoblastic Leukemia
| Status: | Completed |
|---|---|
| Conditions: | Blood Cancer, Blood Cancer, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | Any - 30 |
| Updated: | 5/19/2016 |
| Start Date: | July 2012 |
| End Date: | May 2016 |
Observational - NUP98/JARID1A as a Recurrent Aberration in Pediatric Acute Megakaryoblastic Leukemia
This laboratory study is looking into genes in samples from younger patients with acute
megakaryoblastic leukemia (AMKL). Studying samples of blood, tissue, and bone marrow from
patients with cancer in the laboratory may help doctors learn more about changes that occur
in RNA and identify biomarkers related to cancer
megakaryoblastic leukemia (AMKL). Studying samples of blood, tissue, and bone marrow from
patients with cancer in the laboratory may help doctors learn more about changes that occur
in RNA and identify biomarkers related to cancer
Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective:
Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Cryopreserved
mRNA Study Population Description: Samples from AAML0531 Sampling Method: Non-Probability
Sample
OBJECTIVES:
I. To determine whether NUP98/JARID1A expression is a recurrent translocation in
NUP98-rearranged cases in pediatric acute megakaryoblastic leukemia (AMKL).
II. To screen the Children Oncology Group (COG) samples for genetic aberrations in pediatric
AMKL.
OUTLINE:
Cryopreserved specimens are analyzed for NUP98 fusion to NSD1, JARID1A, and TOP1,
myeloid/lymphoid or mixed-lineage leukemia (MLL)-rearrangements, and other gene expression
profiling by reverse transcriptase polymerase chain reaction (RT-PCR) and karyotyping or
fluorescence in situ hybridization (FISH). Results are then compared with each patient's
outcome data.
Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Cryopreserved
mRNA Study Population Description: Samples from AAML0531 Sampling Method: Non-Probability
Sample
OBJECTIVES:
I. To determine whether NUP98/JARID1A expression is a recurrent translocation in
NUP98-rearranged cases in pediatric acute megakaryoblastic leukemia (AMKL).
II. To screen the Children Oncology Group (COG) samples for genetic aberrations in pediatric
AMKL.
OUTLINE:
Cryopreserved specimens are analyzed for NUP98 fusion to NSD1, JARID1A, and TOP1,
myeloid/lymphoid or mixed-lineage leukemia (MLL)-rearrangements, and other gene expression
profiling by reverse transcriptase polymerase chain reaction (RT-PCR) and karyotyping or
fluorescence in situ hybridization (FISH). Results are then compared with each patient's
outcome data.
Inclusion Criteria:
- Cryopreserved specimens of pediatric patients diagnosed with acute megakaryoblastic
leukemia
We found this trial at
1
site
Monrovia, California 91016
Principal Investigator: Soheil Meshinchi, MD
Phone: 800-422-6237
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