Vortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder

The drug being tested in this study is called vortioxetine. Vortioxetine is being tested for
the prevention of relapse in adults with major depressive disorder (MDD) who respond to daily
treatment with vortioxetine. This study will look at relapse rates of MDD in people who take
vortioxetine.

The study will enroll approximately 1100 participants. All participants will receive
vortioxetine 10 mg open-label for the first 16 weeks of the study. Participants who meet the
appropriate MDD response criteria from the Week 8 Visit through Week 16 Visit will be
eligible for randomization into the double-blind treatment period. Participants will be
randomly assigned (by chance, like flipping a coin) to one of the four treatment groups—which
will remain undisclosed to the patient and study doctor during the study (unless there is an
urgent medical need):

- Vortioxetine 5 mg

- Vortioxetine 10 mg

- Vortioxetine 20 mg

- Placebo (dummy inactive pill) - this is a capsule that looks like the study drug but has
no active ingredient

All participants will be asked to take one capsule at the same time each day throughout the
study.

This multi-center trial will be conducted in the United States. The overall time to
participate in this study is up to 55 weeks. Participants will make 19 visits to the clinic,
and will be contacted by telephone 4 weeks after last dose of study drug for a follow-up
assessment.

Inclusion Criteria:

1. In the opinion of the investigator, the participant is capable of understanding and
complying with protocol requirements.

2. The participant or, when applicable, the participant's legally acceptable
representative signs and dates a written, informed consent form and any required
privacy authorization prior to the initiation of any study procedures.

3. Suffers from recurrent major depressive disorder (MDD) as the primary diagnosis
according to Diagnostic & Statistical Manual of Mental Disorders, 4th Edition - Text
Revision (DSM-IV-TR) criteria (classification code 296.3x), and the current episode is
confirmed by the Mini International Neuropsychiatric Interview (MINI).

4. Reported duration of the current episode is ≥8 weeks and ≤18months.

5. Had at least 2 other major depressive episodes (MDEs) before the current episode.

6. Has a Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥26 at the
Screening and Baseline I visits.

7. Is a man or woman aged 18 to 75 years, inclusive.

8. A female participant of childbearing potential who is sexually active with a
nonsterilized male partner agrees to routinely use adequate contraception from signing
of the informed consent throughout the duration of the study and for 30 days after the
last dose.

Exclusion Criteria:

1. Has received any investigational compound within 30 days prior to screening or 5
half-lives prior to screening, whichever is longer.

2. Has previously or is currently participating in this study.

3. Has participated in 2 or more clinical studies in the year prior to screening, or has
participated in a clinical trial for a psychiatric condition that is exclusionary per
this protocol.

4. Is an immediate family member, study site employee, or is in a dependent relationship
with a study site employee who is involved in conduct of this study (eg, spouse,
parent, child, sibling) or may consent under duress.

5. Has one or more of the following:

1. Any current psychiatric disorder which is the primary focus of treatment other
than MDD as defined in the DSM-IV-TR, and assessed by the MINI.

2. Current or history of: manic or hypomanic episode, schizophrenia or any other
psychotic disorder, including schizoaffective disorder, major depression with
psychotic features, bipolar depression with psychotic features, obsessive
compulsive disorder (OCD), mental retardation, organic mental disorders, or
mental disorders due to a general medical condition as defined in the DSM-IV-TR.

3. Current diagnosis or history of alcohol or other substance abuse or dependence
(excluding nicotine or caffeine) as defined in the DSM-IV-TR that has not been in
full and sustained remission for at least 3 months from the day of screening
(Participant must also have negative urine drug screen at Screening and Baseline
I.)

4. Presence or history of a clinically significant neurological disorder (including
epilepsy) as determined by the investigator.

5. Neurodegenerative disorder (Alzheimer disease, Parkinson disease, multiple
sclerosis, Huntington disease, etc).

6. Any Axis II disorder as defined by DSM-IV-TR that might compromise the study.

6. The current depressive symptoms of the participant are considered by the investigator
to have been resistant to 2 adequate antidepressant treatments of at least 6 weeks
duration each.

7. Has a history of lack of response to previous adequate treatment with vortioxetine for
any MDD episode with adequate treatment considered to be known dose of vortioxetine in
the approved recommended dose range for at least 6 weeks duration.

8. Has received electroconvulsive therapy, vagal nerve stimulation, or repetitive
transcranial magnetic stimulation within 6 months prior to Screening.

9. Has started receiving formal cognitive or behavioral therapy, systematic psychotherapy
within 30 days from screening or plans to initiate such therapy during the study
(supportive therapy, marital therapy and bereavement counseling are allowed).

10. Has a significant risk of suicide according to the investigator's clinical judgment or
has a score ≥5 on item 10 (suicidal thoughts) of the MADRS or has made a suicide
attempt in the previous 6 months.

11. Is required to take excluded medications or it is anticipated that the participant
will require treatment with at least 1 of the disallowed concomitant medications
during the study.

12. Has a clinically significant unstable illness, for example hepatic impairment or renal
insufficiency, or a cardiovascular, pulmonary, gastrointestinal, endocrine,
neurological, rheumatologic, immunologic, hematological, infectious, dermatological
disorder or metabolic disturbance.

Note: For the purposes of this protocol fibromyalgia, obstructive sleep apnea, chronic
pain diagnosis, and morbid obesity (BMI of > 40) are considered unstable due to the
potential impact on assessment of the primary endpoint.

13. Has a known history of or currently has increased intraocular pressure or is at risk
of acute narrow-angle glaucoma.

14. Has 1 or more laboratory value outside the normal range, based on the blood or urine
samples taken at the Screening Visit, that are considered by the investigator to be
clinically significant; or the participant has any of the following values at the
Screening Visit:

1. A serum creatinine value >1.5 times the upper limits of normal (ULN).

2. A serum total bilirubin value >1.5 xULN.

3. A serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) value
>2 xULN.

15. Has glycosylated hemoglobin (HbA1C) ≥7% at screening and no prior diagnosis of
diabetes and/or treatment for diabetes. NOTE: Participants with known stable diabetes
are not excluded.

16. Has a thyroid stimulating hormone (TSH) value outside the normal range at the
Screening Visit that is deemed clinically significant by the investigator. NOTE: Free
T4 will be checked if TSH is out of range. If free T4 is abnormal the participant will
be excluded.

17. Has clinically significant abnormal vital signs as determined by the investigator.

18. Has an abnormal electrocardiogram (ECG) as determined by the central reader and
confirmed as clinically significant by the investigator.

19. Is positive for Hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (HCV)
antibodies, or has a history of human immunodeficiency virus (HIV) infection.

20. Has a disease or takes medication that, in the opinion of the investigator, could
interfere with the assessments of safety, tolerability or efficacy.

21. The participant, in the opinion of the investigator, is unlikely to comply with the
clinical study protocol or is unsuitable for any reason.

22. Has a history of hypersensitivity or allergies to vortioxetine.

23. If female, the participant is pregnant or lactating or intending to become pregnant
before, during, or within 1 month after participating in this study; or intending to
donate ova during such time period.

24. The subject is considered to be treatment resistant, eg, the subject has not responded
to adequate monotherapy treatments of at least 6 weeks' duration, or has only
responded to combination or augmentation therapy.