Longitudinal Family/Molecular Genetic Study to Validate Research Domain Criteria

The NIMH Research Domain Criteria (RDoC) initiative seeks to further a long-range goal of
contributing to diagnostic systems as informed by research on genetics, neuroscience, and
behavior. The RDoC approach is based on identifying the most elemental units of analysis
relevant to psychiatric disorders (such as genes and molecules) and using this matrix as a
framework for investigation. In this case-control family study, the investigators will be
using self-report questionnaires and computer-based tests to develop diagnostic methods for
neuropsychiatric disorders in children, their siblings, and their parents. They will do this
by recruiting "normal" and "affected" children, their siblings, and their parents. They will
look at the subject, sibling, and parents to determine if psychiatric disorders are
inherited. "Affected" children, ages 6-12, are those who have been diagnosed with a
psychiatric disorder. Participants will undergo a battery of questionnaires/evaluations and a
blood draw. The investigators will determine if the questionnaires and tests that reflect the
constructs (such as reward prediction and willingness to work) predict psychopathology and
impairment. The blood draw will be genotyped to determine if the measured constructs are
associated with neuropsychiatric candidate genes, cross-disorder candidate gens and a
cross-disorder polygenic score.

Inclusion Criteria:

- male or female, ages 6-12.

- biological child of parent(s) participating in testing.

Exclusion Criteria:

- taking psychotropic medications.

- free of uncontrolled medical problems.

- major sensorimotor disability (e.g., deafness, blindness).

- diagnosed neurological condition.

- inadequate command of the English language.

- history of head injury with loss of consciousness lasting longer than 10 minutes.

- IQ estimated at below 80.