A Randomized Controlled Trial of Oral Acetaminophen for Analgesic Control After Transvaginal Oocyte Retrieval
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 21 - 45 |
| Updated: | 11/4/2018 |
| Start Date: | January 2015 |
| End Date: | July 2016 |
Current standard of care is no pretreatment medications before the egg retrieval, and the
investigators would like to evaluate if preoperative Tylenol improves procedure and post
procedure pain control over the current practice (no pre-treatment). Specifically, this study
will compare Tylenol with a placebo when given before retrieval procedures. The investigators
believe that if Tylenol can offer better analgesic relief than no pretreatment medications,
then it may reduce the amount of narcotics needed by patients during and after the procedure
and contribute to better patient satisfaction. . This study will enroll 100 participants all
from UAB.
investigators would like to evaluate if preoperative Tylenol improves procedure and post
procedure pain control over the current practice (no pre-treatment). Specifically, this study
will compare Tylenol with a placebo when given before retrieval procedures. The investigators
believe that if Tylenol can offer better analgesic relief than no pretreatment medications,
then it may reduce the amount of narcotics needed by patients during and after the procedure
and contribute to better patient satisfaction. . This study will enroll 100 participants all
from UAB.
The current standard of care for oocyte retrieval in IVF involves fentanyl, propofol, as well
as oxycodone. However, there exists little data of alternatives to narcotic medications for
analgesic purposes in oocyte retrieval procedures. A retrospective study published in 2013
showed potential for NSAID's, specifically ketorolac, to significantly improve pain scores in
women undergoing oocyte retrieval (Mesen et al). It was also shown that the use of these
medications did not significantly alter pregnancy rate, live birth rate, or miscarriage rate
in these patients. Few other studies have delved into the question of anesthetics for oocyte
retrievals except a prospective study in 2006. This study, performed by Akande et al, shows
that no significant difference in pregnancy rates of implantation occurs with the use of
acetaminophen and diclofenac vs. acetaminophen alone if given post-operatively. However, pain
was not measured in this study for either group. Therefore, it is clear that there exists
limited data on the subject of analgesics used in oocyte retrievals for in vitro
fertilization and that more exploration into alternative medications is required to find the
most effective and least harmful option.
as oxycodone. However, there exists little data of alternatives to narcotic medications for
analgesic purposes in oocyte retrieval procedures. A retrospective study published in 2013
showed potential for NSAID's, specifically ketorolac, to significantly improve pain scores in
women undergoing oocyte retrieval (Mesen et al). It was also shown that the use of these
medications did not significantly alter pregnancy rate, live birth rate, or miscarriage rate
in these patients. Few other studies have delved into the question of anesthetics for oocyte
retrievals except a prospective study in 2006. This study, performed by Akande et al, shows
that no significant difference in pregnancy rates of implantation occurs with the use of
acetaminophen and diclofenac vs. acetaminophen alone if given post-operatively. However, pain
was not measured in this study for either group. Therefore, it is clear that there exists
limited data on the subject of analgesics used in oocyte retrievals for in vitro
fertilization and that more exploration into alternative medications is required to find the
most effective and least harmful option.
Inclusion Criteria:
- English Speaking
- Undergoing Transvaginal Oocyte Retrieval Procedure
Exclusion Criteria:
- Acetaminophen allergy
- Opioid dependency
We found this trial at
1
site
1720 2nd Ave S
Birmingham, Alabama 35233
Birmingham, Alabama 35233
(205) 934-4011
Phone: 205-934-1030
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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