HemoSonics-UVA Spinal Surgery

HemoSonics is developing a novel POC diagnostic device, the Quantra System, to perform whole
blood coagulation analysis and which is suitable for use in surgical and intensive care
settings. The Quantra System employs a patented technology named sonorheometry, which was
invented at the University of Virginia.

Sonorheometry uses ultrasound pulses to characterize the dynamic changes in viscoelastic
properties of a blood sample during coagulation and clot lysis. The initial assay performed
on the Quantra System will be the surgical assay for monitoring hemostasis during major
surgical procedures in adult patients.

A clinical study will be conducted to evaluate the analytical performance as well as
compared to existing coagulation monitoring technology

Inclusion Criteria:

- • Subject is scheduled for major deformity correction spine surgery

- Subject is older than 18 years

- Subject is willing to participate and he/she has signed a consent form

Exclusion Criteria:

- • Subject is unable to provide written informed consent

- Subject is incarcerated at the time of the study

- Subject is affected by any condition that, in the opinion of the surgical team,
may pose additional risks

- Subjects with renal disease (defined as serum creatinine greater than 1.5 mg/dl)

- Subjects with history of active liver disease

- Subjects affected by Factor V Leiden mutation

- Subjects affected by von Willebrand disease

- Subjects with an history of thrombotic disease (more than one DVT)