Mechanisms of Altered Ventilatory Control in Heart Failure
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 2/8/2019 |
| Start Date: | July 2012 |
| End Date: | December 2019 |
| Contact: | Eric Bruhn |
| Phone: | 507-255-7125 |
This study is being done because the investigators are trying to understand how feedback from
the muscles can influence your blood pressure and breathing during exercise, and if the
investigators can reduce this response in heart failure patients. The investigators are also
trying to determine ways to improve tolerance to exercise in heart failure patients.
the muscles can influence your blood pressure and breathing during exercise, and if the
investigators can reduce this response in heart failure patients. The investigators are also
trying to determine ways to improve tolerance to exercise in heart failure patients.
If you are enrolled in this study the investigators will ask you to make 3 separate study
visits.
During study visit 1 you will be asked to get a blood draw, DEXA bone scan, perform pulmonary
function tests, and exercise on a stationary bike at maximal exertion while breathing into a
mouth piece.
During study visits 2 and 3 you will be asked to again exercise at maximal exertion while
breathing into a mouth piece. However, during these two visits you will be receiving an
intrathecal injection of fentanyl one day and placebo the other day, randomly selected and
you will be blinded as to which you are receiving. A catheter will also be placed in an
artery in your arm and a vein in your leg, which will help us to measure blood flow, blood
pressure and draw blood when need be. The investigators will also ask you to perform a brief
chemosensitivity test, breathing in and out your own air, after you are done exercising.
visits.
During study visit 1 you will be asked to get a blood draw, DEXA bone scan, perform pulmonary
function tests, and exercise on a stationary bike at maximal exertion while breathing into a
mouth piece.
During study visits 2 and 3 you will be asked to again exercise at maximal exertion while
breathing into a mouth piece. However, during these two visits you will be receiving an
intrathecal injection of fentanyl one day and placebo the other day, randomly selected and
you will be blinded as to which you are receiving. A catheter will also be placed in an
artery in your arm and a vein in your leg, which will help us to measure blood flow, blood
pressure and draw blood when need be. The investigators will also ask you to perform a brief
chemosensitivity test, breathing in and out your own air, after you are done exercising.
Inclusion Criteria (Heart Failure Patients):
- History of ischemic or idiopathic dilated cardiomyopathy
- New York Heart Association class 1-3
- No history of dangerous arrhythmia's
- Not pacemaker dependent
- Body Mass Index less than or equal to 35 kg/m
- Current non-smokers with less than 15 pack year history
- Non-pregnant women
- Individuals who are able to exercise without orthopedic limitations
- All patients will be managed by their primary care physician or cardiologist prior to
enrollment to ensure inclusion and exclusion criteria have been satisfied and
participation in exercise testing is safe.
Control Participants:
- Will be matched for age, gender, height and weight and will have no history of
cardiovascular related abnormalities.
- Body Mass Index less than 35 kg/m
- Current non-smokers with less than 15 pack year history
- Non-pregnant women
- Individuals who are able to exercise without orthopedic limitations
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