Imaging Acquisition and Analysis Methods for Optimization of MRI Radiation Oncology Simulation and Response Assessment
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/15/2019 |
| Start Date: | April 9, 2015 |
| End Date: | April 2020 |
| Contact: | Nancy Lee, MD |
| Phone: | 212-639-3341 |
Development and Evaluation of Imaging Acquisition and Analysis Methods for Optimization of MRI Radiation Oncology Simulation and Response Assessment
Magnetic resonance imaging (MRI) is currently one of the standard diagnostic imaging methods
used to diagnose tumor stage before treatment in Radiology Oncology Department. It is also
used to check responses to radiation after treatment. However, MRI isn't traditionally used
in planning for radiation treatment or in checking treated tumor and tissue changes during
radiation treatment. The goal is to find out the possible benefits of MRI imaging techniques
in these settings of radiation treatment. Participating in this study would NOT change the
current treatment plans, this will allow the investigators to use the MRI methods in research
and future patient care.
used to diagnose tumor stage before treatment in Radiology Oncology Department. It is also
used to check responses to radiation after treatment. However, MRI isn't traditionally used
in planning for radiation treatment or in checking treated tumor and tissue changes during
radiation treatment. The goal is to find out the possible benefits of MRI imaging techniques
in these settings of radiation treatment. Participating in this study would NOT change the
current treatment plans, this will allow the investigators to use the MRI methods in research
and future patient care.
The purpose of this protocol is to demonstrate proof of concept and feasibility of new MRI
hardware, pulse sequences and data analysis software to plan radiotherapy treatment and to
assess tumor response to radiotherapy (only FDA approved hardware are allowed in this study).
Efforts to develop, modify and evaluate new or existing MR imaging techniques must be a
continuous practice with the goal of enhancing the use of MRI during radiation therapy. The
investigators therefore anticipate an ongoing need for such a protocol and believe the
ability to perform such studies is critical to the translation of new imaging technologies
from concept to routine clinical use. Under this protocol, modifications to the following
items may be tested: pulse sequence programs, radiofrequency coils, reconstruction and
processing software, other MR system hardware and analysis software. A brief description of
each of these items is described below. The potential risks associated with modifying each of
these items, and the measures that will be taken to minimize these risks are described in
subsequent sections.
Given that performing MRI examinations during radiation therapy is not the current standard
of care, no changes to radiation treatment plans, radiotherapy delivery or treatment
recommendations or guidelines will be done based on the findings for any participants entered
on this protocol.
hardware, pulse sequences and data analysis software to plan radiotherapy treatment and to
assess tumor response to radiotherapy (only FDA approved hardware are allowed in this study).
Efforts to develop, modify and evaluate new or existing MR imaging techniques must be a
continuous practice with the goal of enhancing the use of MRI during radiation therapy. The
investigators therefore anticipate an ongoing need for such a protocol and believe the
ability to perform such studies is critical to the translation of new imaging technologies
from concept to routine clinical use. Under this protocol, modifications to the following
items may be tested: pulse sequence programs, radiofrequency coils, reconstruction and
processing software, other MR system hardware and analysis software. A brief description of
each of these items is described below. The potential risks associated with modifying each of
these items, and the measures that will be taken to minimize these risks are described in
subsequent sections.
Given that performing MRI examinations during radiation therapy is not the current standard
of care, no changes to radiation treatment plans, radiotherapy delivery or treatment
recommendations or guidelines will be done based on the findings for any participants entered
on this protocol.
Inclusion Criteria:
- Men and women age 18 or older
Exclusion Criteria:
- Anyone who would be normally excluded from undergoing an MRI examination as per
Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire
- Participants/volunteers with a pacemaker, aneurysm clip or any other condition that
would warrant avoidance of a strong magnetic field
- Female participants/volunteers who are pregnant or nursing
- Participants/Volunteers who are unable to comply or complete the MRI exam due to
claustrophobia or high levels of anxiety
- Participants/Volunteers from the vulnerable population, as defined by 45 CFR 46.
- Participants at higher risk due to age, frailty, or the emergent nature of their
condition.
We found this trial at
1
site
1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Principal Investigator: Nancy Lee, MD
Phone: 212-639-3341
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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