UT-15C SR in the Treatment of Critical Limb Ischemia
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 45 - 85 |
| Updated: | 4/2/2016 |
| Start Date: | November 2006 |
An Investigator Initiated Eight Week Two Center Open-Label Pilot Study of the Tolerability and Safety of Oral UT-15C (Treprostinil Diethanolamine)SR Tablets in Patients With Critical Limb Ischemia (CLI) and Ischemic Rest Pain
This study will evaluate UT-15C sustained release tablets in subjects experiencing ischemic
lower limb rest pain related to advanced peripheral arterial disease. Rest pain is one of
the primary management issues of severe arterial occlusive disease and may lead to
amputation when the pain becomes intolerable and unresponsive to narcotic analgesia. Rest
pain also impacts the quality of sleep and mobility with frequent interruptions in sleep and
decreased mobility. Treprostinil sodium (Remodulin®) has been studies in several small
open-label studies and has been shown to be safe as well as an effective agent for ischemic
rest pain when given by subcutaneous or intravenous delivery. However, these forms of
administration have patient convenience limitations, including the need for an infusion
device and associated pain at the site of infusion with subcutaneous delivery. UT-15C may
allow patients suffering from CLI to benefit from the simplicity of an oral dosage form
lower limb rest pain related to advanced peripheral arterial disease. Rest pain is one of
the primary management issues of severe arterial occlusive disease and may lead to
amputation when the pain becomes intolerable and unresponsive to narcotic analgesia. Rest
pain also impacts the quality of sleep and mobility with frequent interruptions in sleep and
decreased mobility. Treprostinil sodium (Remodulin®) has been studies in several small
open-label studies and has been shown to be safe as well as an effective agent for ischemic
rest pain when given by subcutaneous or intravenous delivery. However, these forms of
administration have patient convenience limitations, including the need for an infusion
device and associated pain at the site of infusion with subcutaneous delivery. UT-15C may
allow patients suffering from CLI to benefit from the simplicity of an oral dosage form
This study is an eight week, two center, open-label study assessing the tolerability,
safety, and efficacy of oral UT-15C sustained release tablets in subjects with CLI and
ischemic lower limb rest pain, with or without an ischemic wound present. Conventional
therapy should be continued without changes over the course of the study for all subjects.
Group 1: The first ten subjects to enroll in the study will be assigned to receive an
initial dose of 1mg. The dose will be titrated upward every seven days, depending on
tolerability, to a maximum dose of 4mg/day .
Group 2: The last ten subjects to enroll in the study will be assigned to receive an initial
dose of 1mg. The dose will be titrated upward every seven days, depending on tolerability to
a maximum dose of 8 mg/day .
safety, and efficacy of oral UT-15C sustained release tablets in subjects with CLI and
ischemic lower limb rest pain, with or without an ischemic wound present. Conventional
therapy should be continued without changes over the course of the study for all subjects.
Group 1: The first ten subjects to enroll in the study will be assigned to receive an
initial dose of 1mg. The dose will be titrated upward every seven days, depending on
tolerability, to a maximum dose of 4mg/day .
Group 2: The last ten subjects to enroll in the study will be assigned to receive an initial
dose of 1mg. The dose will be titrated upward every seven days, depending on tolerability to
a maximum dose of 8 mg/day .
Inclusion Criteria:
1. Have an ankle systolic pressure ≤ 60 mm/Hg OR ABI ≤ 0.60 OR toe systolic pressure ≤
60 mm/Hg OR an arteriogram showing at least one level of occlusion of lower extremity
arteries.
2. Have been taking analgesics to control ischemic rest pain for at least two weeks at
Baseline.
3. Have signed an appropriate consent for participation in this study.
4. If female, be physiologically incapable of childbearing or practicing acceptable
methods of birth c
Exclusion Criteria:
1. Have had a vascular surgery or other vascular procedure to treat their CLI within 30
days prior to study entry.
2. Have a planned or scheduled vascular surgery or endovascular procedure.
3. Be currently taking any investigational drugs for CLI.
4. Have received prostaglandins such as PGE1, epoprostenol (Flolan®), or any other
prostacyclin (PGI2) or prostacyclin analog in the past 30 days.
5. Be hemodynamically unstable or have acute renal failure, cardiac failure or pulmonary
failure.
6. Have a diagnosis of Stage IVb (Fontaine) or Stage 6 (Rutherford scale) Critical Limb
Ischemia due to documented peripheral arterial disease
7. Have an unhealed incision(s) from a toe or transmetatarsal amputation at Baseline.
8. Have any wound with significant gangrene or exposed tendons.
We found this trial at
2
sites
801 N Rutledge St
Springfield, Illinois 62702
Springfield, Illinois 62702
(217) 545-8000
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