Characterization of the Plasma Proteome Following Left Ventricular Assist Device Implantation

Inclusion Criteria:

- Planned HeartMate II LVAD implantation

- Planned warfarin (goal INR, 2.0-3.0) and low-dose aspirin therapy post-LVAD placement

Exclusion Criteria:

- Prior history of mechanical circulatory support;

- Body weight < 110 lbs;

- Pre-existing hemolytic, bleeding, or immunologic disorders prior to LVAD
implantation;

- Severe aortic stenosis;

- Renal failure requiring dialysis;

- Hepatic dysfunction resulting in severe coagulopathies;

- Recent serious infection;

- Current need for prolonged ventilatory support;

- Prior organ transplantation;

- Blood transfusion within 14 days of the first planned study blood draw;

- Concomitant immunosuppressant or chemotherapeutic agents;

- Pregnant women;

- Decisionally challenged or prisoners;

- Unwilling to provide written informed consent