A Study of TRC105 in Combination With Paclitaxel/Carboplatin and Bevacizumab in Non-Squamous Cell Lung Cancer

Advanced non-small cell lung cancer has been historically difficult to treat, and novel
agents are in dire need.TRC105 has been shown to enhance the anti-angiogenic effect of
bevacizumab and may result in more effective angiogenesis inhibition and improved clinical
efficacy when combined with bevacizumab and paclitaxel/carboplatin. Participants will be
treated with the combination drugs for 6 cycles of therapy (3 weeks per cycle) and may or may
not be placed on maintenance therapy depending upon the induction response. Maintenance
therapy will continue until there is disease progression, unacceptable toxicity, or patient
withdrawal. Blood collections and tumor assessments will be performed throughout the study.

Inclusion Criteria:

- Treatment-naïve, stage 4 Non-Squamous Cell Lung Cancer

- Measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST).

- Age of 19 years or older.

- Eastern Cooperative Oncology Group (ECOG) performance status ≤1.

- Resolution of all acute adverse events resulting from prior cancer therapies to NCI
Common Terminology Criteria for Adverse Events (CTCAE) grade ≤1 or baseline (except
alopecia or neuropathy).

- Adequate organ function as defined by the following criteria:

- Serum aspartate transaminase (AST; serum glutamate oxaloacetate transaminase [SGOT])
and serum alanine transaminase (ALT; serum glutamate pyruvate transaminase [SGPT])
≤2.5 x upper limit of normal (ULN) or ≤5 x ULN in cases of liver metastases.

- Total serum bilirubin ≤1.5 times the upper limit of normal.

- Absolute neutrophil count (ANC) ≥1500/μL.

- Platelets ≥100,000/μL without transfusion support within the past 28 days.

- Hemoglobin ≥9.0 g/dL without transfusion support within the past 28 days
(erythropoietin or darbepoietin permitted).

- Serum creatinine ≤1.5 times the upper limit of normal or creatinine clearance >30
mL/min by Cockcroft-Gault formula.

- International Normalized Ratio (INR) from 0.8 to 1.2.

- Willingness and ability to consent for self to participate in study.

- Willingness and ability to comply with scheduled visits, treatment plan, laboratory
tests, and other study procedures.

Exclusion Criteria:

- Non-small cell lung cancer of squamous histology.

- Prior treatment with TRC105.

- Current treatment on another therapeutic clinical trial.

- Receipt of a small molecule anticancer agent, including an investigational anticancer
small molecule, within 14 days of starting study treatment.

- Receipt of a large molecule anticancer agent (e.g., antibody), including an
investigational anticancer antibody, within 28 days of starting study treatment.

- No major surgical procedure or significant traumatic injury within 6 weeks prior to
study registration, and must have fully recovered from any such procedure; date of
surgery (if applicable) or the anticipated need for a major surgical procedure within
the next six months. The following are not considered to be major procedures and are
permitted up to 7 days before therapy initiation: thoracentesis, paracentesis, port
placement, laparoscopy, thorascopy, tube thoracostomy, bronchoscopy, endoscopic
ultrasonographic procedures, mediastinoscopy, skin biopsies, incisional biopsies,
imaging-guided biopsy for diagnostic purposes, and routine dental procedures.

- Patients who have received wide field radiotherapy ≤28 days (defined as >50% of volume
of pelvic bones or equivalent) or limited field radiation for palliation <14 days
prior to study registration or those patients who have not recovered adequately from
side effects of such therapy.

- Uncontrolled chronic hypertension defined as systolic >150 or diastolic >90 despite
optimal therapy (initiation or adjustment of BP medication prior to study entry is
allowed provided that the average of 3 BP readings at a visit prior to enrollment is
<140/90 mm Hg).

- History of brain involvement with cancer, spinal cord compression, or carcinomatous
meningitis, or new evidence of brain or leptomeningeal disease. Patients with radiated
or resected lesions are permitted, provided the lesions are fully treated and
inactive, patients are asymptomatic, and no steroids have been administered for at
least 28 days.

- Angina, myocardial ischemia (MI), symptomatic congestive heart failure,
cerebrovascular accident, transient ischemic attack, arterial embolism, pulmonary
embolism, percutaneous transluminal coronary angioplasty (PTCA) or coronary artery
bypass graft (CABG) within the past 6 months. Deep venous thrombosis within 6 months,
unless the patient is anticoagulated without the use of warfarin for at least 2 weeks.
In this situation, low molecular weight heparin is preferred.

- Active bleeding or pathologic condition that carries a high risk of bleeding (e.g.
hereditary hemorrhagic telangiectasia). Patients who have been uneventfully
anticoagulated with low molecular weight heparin are eligible.

- Thrombolytic use (except to maintain i.v. catheters) or anticoagulant use within 10
days prior to first day of study therapy.

- Cardiac dysrhythmias of NCI CTCAE grade ≥2 within the last 28 days.

- Known active viral or nonviral hepatitis or cirrhosis.

- History of hemorrhage or hemoptysis (>½ teaspoon bright red blood) within 3 months of
starting study treatment.

- History of peptic ulcer disease or erosive gastritis within the past 3 months, unless
treated for the condition and complete resolution has been documented by
esophagogastroduodenoscopy (EGD) within 28 days of starting study treatment.

- History of gastrointestinal perforation or fistula in the past 6 months, or while
previously on antiangiogenic therapy, unless underlying risk has been resolved (e.g.,
through surgical resection or repair).

- Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)
related illness.

- Pregnancy or breastfeeding. Female patients must be surgically sterile (i.e.:
hysterectomy) or be postmenopausal, or must agree to use effective contraception
during the study and for 3 months following last dose of TRC105. All female patients
of reproductive potential must have a negative pregnancy test (serum or urine) within
7 days prior to first dose. Male patients must be surgically sterile or must agree to
use effective contraception during the study and for 3 months following last dose of
TRC105.

- Other severe acute or chronic medical or psychiatric condition or laboratory
abnormality that may increase the risk associated with study participation or may
interfere with the interpretation of study results.