Randomized Controlled Clinical Trial of Cinnamon to Lower Hemoglobin A1c
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 2/9/2019 |
| Start Date: | March 2007 |
| End Date: | August 2007 |
A Randomized Controlled Clinical Trial Comparing the Effect of 1g of Daily Cinnamon Plus Usual Care to Usual Cre on the Hemoglobin A1c of Uncontrolled Type 2 Diabetics
This study will randomize diabetics with hemoglobin A1c greater than 7.0 to receive either
cinnamon plus usual care or usual care alone. Hemoglobin A1c will be measured at intake and
after 90 days.
cinnamon plus usual care or usual care alone. Hemoglobin A1c will be measured at intake and
after 90 days.
As the worldwide incidence of diabetes increases, the search for dietary adjuncts to treat
this life-altering disease becomes far ranging. Cinnamon is purported to be a natural insulin
sensitizer without any known adverse events. Both in vitro and in vivo animal studies have
shown that cinnamon is an insulin sensitizer1. Several compounds within cinnamon have been
identified as possible sources of this sensitization process.
To-date, three small randomized trials studying cinnamon in human diabetics have been
published. Khan et al. reported that fasting serum glucose could be reduced by 18-29% after
40 days of supplementation with 1, 3, or 6 g of cinnamon (Cinnamomum cassia) in type 2
diabetics. 2 This study had several limitations that included failure to measure hemoglobin
A1C, all patients were Pakistani, and no power analysis was documented. Vanschoonbeek, et
al.3 report a small RCT of postmenopausal women with well-controlled type 2 diabetes which
showed no change in HbA1C or fasting glucose. Once again no power analysis is reported. Mang
et al. 4 conducted a RCT of type 2 diabetics treated with aqueous extract of cinnamon for 4
months. They report a 15% decrease in fasting glucose and no change in HbA1C over the
duration of this trial. Subjects had HbA1C less than 7% and again no power analysis was
included in this study.
This study will address whether cinnamon at the dose of 1g daily in addition to usual care
lowers hemoglobin A1c compared to usual care. Power analysis indicates that 63 per group are
needed and we will recruit 70 patients.
this life-altering disease becomes far ranging. Cinnamon is purported to be a natural insulin
sensitizer without any known adverse events. Both in vitro and in vivo animal studies have
shown that cinnamon is an insulin sensitizer1. Several compounds within cinnamon have been
identified as possible sources of this sensitization process.
To-date, three small randomized trials studying cinnamon in human diabetics have been
published. Khan et al. reported that fasting serum glucose could be reduced by 18-29% after
40 days of supplementation with 1, 3, or 6 g of cinnamon (Cinnamomum cassia) in type 2
diabetics. 2 This study had several limitations that included failure to measure hemoglobin
A1C, all patients were Pakistani, and no power analysis was documented. Vanschoonbeek, et
al.3 report a small RCT of postmenopausal women with well-controlled type 2 diabetes which
showed no change in HbA1C or fasting glucose. Once again no power analysis is reported. Mang
et al. 4 conducted a RCT of type 2 diabetics treated with aqueous extract of cinnamon for 4
months. They report a 15% decrease in fasting glucose and no change in HbA1C over the
duration of this trial. Subjects had HbA1C less than 7% and again no power analysis was
included in this study.
This study will address whether cinnamon at the dose of 1g daily in addition to usual care
lowers hemoglobin A1c compared to usual care. Power analysis indicates that 63 per group are
needed and we will recruit 70 patients.
Inclusion Criteria:
- Type 2 diabetics greater tahn 18 years of age
Exclusion Criteria:
- allergy to cinnamon pregnancy
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