Brain Connectivity and Mindfulness Training in Youth With Bipolar Disorder Not Otherwise Specified (NOS)
| Status: | Terminated |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 13 - 17 |
| Updated: | 7/21/2018 |
| Start Date: | May 2014 |
| End Date: | September 2017 |
Brain Connectivity and Mindfulness Training in Youth With Bipolar Disorder NOS
The investigators propose to study 30 adolescents with bipolar disorder, not otherwise
specified (BD NOS) and a family history of Bipolar I Disorder (BD) at baseline with rs-fMRI
(functional magnetic resonance imaging) and functional connectivity (FC) analyses and compare
data with previously acquired rs-fMRI and FC data from 20 age- and gender-matched healthy
controls (HC). Subjects will then undergo a 12-week Mindfulness based stress reduction- teen
(MBSR-T) intervention and be reassessed and rescanned. The intervention and scanning will
take place in groups of 6-8 subjects/group/year over the 4 years. This proposal will be a
natural progression of past research, while extending the investigators' expertise to include
advanced FC analyses and mindfulness based interventions in youth with mood dysregulation.
The investigators will also integrate trainees into the imaging and therapy components of
this study, furthering our mission of mentoring the next generation of innovative researchers
who will push the field forward.
specified (BD NOS) and a family history of Bipolar I Disorder (BD) at baseline with rs-fMRI
(functional magnetic resonance imaging) and functional connectivity (FC) analyses and compare
data with previously acquired rs-fMRI and FC data from 20 age- and gender-matched healthy
controls (HC). Subjects will then undergo a 12-week Mindfulness based stress reduction- teen
(MBSR-T) intervention and be reassessed and rescanned. The intervention and scanning will
take place in groups of 6-8 subjects/group/year over the 4 years. This proposal will be a
natural progression of past research, while extending the investigators' expertise to include
advanced FC analyses and mindfulness based interventions in youth with mood dysregulation.
The investigators will also integrate trainees into the imaging and therapy components of
this study, furthering our mission of mentoring the next generation of innovative researchers
who will push the field forward.
Inclusion Criteria:
- Ages 13-17
- Diagnosed with BD-NOS
- First or second degree relative diagnosed with bipolar I or II
Exclusion Criteria:
- Not English speaking
- For those who are to participate in the MRI scan, having any metal in the body or
movement disorders will be an exclusionary factor
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