Resistance Training in HFpEF
Status: | Recruiting |
---|---|
Conditions: | Cardiology |
Therapuetic Areas: | Cardiology / Vascular Diseases |
Healthy: | No |
Age Range: | 18 - 80 |
Updated: | 11/9/2018 |
Start Date: | June 2015 |
End Date: | January 2019 |
Contact: | Eric Bruhn, MA |
Phone: | 507-266-4178 |
Resistance Exercise Training in Heart Failure With Preserved Ejection Fraction (Resist - HFpEF)
The objective of this proposal is to determine the effect of resistance exercise training on
locomotor muscle function, exercise capacity, exertional symptoms, and quality of life in HF
patients with preserved ejection fraction (HFpEF).
locomotor muscle function, exercise capacity, exertional symptoms, and quality of life in HF
patients with preserved ejection fraction (HFpEF).
In this randomized controlled pilot study of resistance exercise training in patients with
HFpEF, the investigators will recruit 24 HFpEF patients who will be randomized to resistance
exercise training (RT - n=12) or no resistance exercise training (standard care control group
[CTL] - n=12). The investigators will have baseline and follow-up measures of clinical
characteristics, leg muscle strength, quality of life, lean muscle mass (body composition via
DXA including segmental lean mass), maximal cardiopulmonary exercise test (peak VO2, peak
work, ventilatory efficiency), constant-load submaximal cardiopulmonary exercise test with
speckle tracking echocardiography (exertional dyspnea and fatigue at matched workloads,
cardiac output, diastolic function, left ventricular strain, ventilation, gas exchange, and
locomotor muscle neural feedback).
Participants will be asked to make 4 separate study visits. Those randomized to undergo
Resistance Training will be expected to make those visits as well.
HFpEF, the investigators will recruit 24 HFpEF patients who will be randomized to resistance
exercise training (RT - n=12) or no resistance exercise training (standard care control group
[CTL] - n=12). The investigators will have baseline and follow-up measures of clinical
characteristics, leg muscle strength, quality of life, lean muscle mass (body composition via
DXA including segmental lean mass), maximal cardiopulmonary exercise test (peak VO2, peak
work, ventilatory efficiency), constant-load submaximal cardiopulmonary exercise test with
speckle tracking echocardiography (exertional dyspnea and fatigue at matched workloads,
cardiac output, diastolic function, left ventricular strain, ventilation, gas exchange, and
locomotor muscle neural feedback).
Participants will be asked to make 4 separate study visits. Those randomized to undergo
Resistance Training will be expected to make those visits as well.
All patients will be managed by their primary care physician or cardiologist with
additional review and oversight by Dr. Borlaug (Co-Investigator) prior to enrollment to
ensure adequacy of inclusion and exclusion criteria and that participation in exercise
testing and resistance exercise training is safe.
Inclusion Criteria, includes:
- Clinical diagnosis of HFpEF.
- Patients 18-80 yrs old with a history stable (no medication changes in past 6 weeks
(w/duration of diagnosis >6 months).
- New York Heart Association class I-III.
- Ejection fraction ≥40%.
- Current non-smokers with <15 pack year history.
- Non-pregnant women, and individuals who are able to exercise (i.e. without orthopedic
limitations or neuromuscular disorders).
Exclusion Criteria, includes:
- Patient refusal to participate.
- Significant orthopedic or neuromuscular limitations
- Significant cognitive impairment
- Hemoglobin < 7.0 g/d.
We found this trial at
1
site
200 First Street SW
Rochester, Minnesota 55905
Rochester, Minnesota 55905
507-284-2511
Phone: 507-266-4178
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
Click here to add this to my saved trials