Racial and Genetic Biomarkers of Response in Tissue Samples From Patients With Endometrial Cancer

PRIMARY OBJECTIVES:

I. To identify racial categorization as the proportion of genetic background of
African-American or European-American women with endometrioid endometrial cancer (EEC).

II. To evaluate the association of racial genetic admixture with clinicopathologic variables
and outcomes.

SECONDARY OBJECTIVES:

I. To compare the concordance between racial genetic admixture and self-designated race
categorization.

OUTLINE: This is a multicenter study. Patients are stratified by race (African-American vs
European-American) and disease stage (I vs II vs III vs IV).

DNA from archived frozen normal tissue samples is genotyped for the ancestry informative
markers. Clinicopathological and demographic characteristics associated with each sample are
also collected.

Inclusion Criteria:

- Histologically confirmed endometrial cancer

- Stage I-IV disease regardless of grade

- Underwent surgical staging including hysterectomy, bilateral oophorectomy,
washings, and pelvic lymphadenectomy

- Eligible and evaluated on GOG-0210 clinical trial, a Molecular Staging Study in
Endometrial Cancer

- Available frozen or formalin-fixed and paraffin-embedded normal tissue that is free
of tumor cells and yields sufficient high-quality normal DNA for testing

- Consented their specimens and clinical data to be collected and used in future
studies

- Self-declared African-American or Caucasian race