Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell Disease



Status:Recruiting
Conditions:Anemia
Therapuetic Areas:Hematology
Healthy:No
Age Range:6 - Any
Updated:3/16/2019
Start Date:June 17, 2015
End Date:June 22, 2019
Contact:Pfizer CT.gov Call Center
Email:ClinicalTrials.gov_Inquiries@pfizer.com
Phone:1-800-718-1021

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF RIVIPANSEL (GMI-1070) IN THE TREATMENT OF VASO-OCCLUSIVE CRISIS IN HOSPITALIZED SUBJECTS WITH SICKLE CELL DISEASE

This is a clinical study evaluating the efficacy and safety of rivipansel (GMI-1070) in
treating subjects with sickle cell disease (SCD) who are 6 years of age or older experiencing
a pain crisis necessitating hospitalization.


Inclusion Criteria:

- At least 6 years of age.

- Documented diagnosis of sickle cell disease.

- Diagnosis of vaso-occlusive crisis necessitating admission to the hospital with
treatment including IV opioids.

- Able to receive the first dose of study drug within 24 hours from the administration
of IV opioids.

Exclusion Criteria:

- Serious systemic infection

- Acute Chest Syndrome

- Serious concomitant medical problems (for example, stroke)

- SCD pain atypical of VOC

- Severe renal or hepatic impairment

- Chronic pain rather than a presentation of acute VOC
We found this trial at
137
sites
Children's Hospital of Philadelphia, Investigational Drug Service
3401 Civic Center Boulevard
Philadelphia, Pennsylvania 19104
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
?
mi
from
Boston, MA
Click here to add this to my saved trials
University of Chicago Comer Children's Hospital
5721 S. Maryland Avenue
Chicago, Illinois 60637
?
mi
from
Chicago, IL
Click here to add this to my saved trials
University of Cincinnati Medical Center
234 Goodman Dr
Cincinnati, Ohio 45229
(513) 584-1000
University of Cincinnati Medical Center Opening in 1823 as the country
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Nationwide Children's Hospital
700 Childrens Drive
Columbus, Ohio 43205
(616) 722-2000
Nationwide Children's Hospital At Nationwide Children’s, we are creating the future of pediatric health care....
?
mi
from
Columbus, OH
Click here to add this to my saved trials
University of Mississippi Medical Center
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
Jackson Memorial Hospital
1500 Northwest 12th Avenue # 106
Miami, Florida 33136
?
mi
from
Miami, FL
Click here to add this to my saved trials
University of Miami
Miami, Florida 33124
(305) 284-2211
University of Miami A private research university with more than 15,000 students from around the...
?
mi
from
Miami, FL
Click here to add this to my saved trials
Children's Hospital of Philadelphia
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Children's Hospital of Pittsburgh of UPMC
4401 Penn Avenue
Pittsburgh, Pennsylvania 15224
412-692-5325
Children's Hospital of Pittsburgh of UPMC UPMC is one of the leading nonprofit health systems...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Rhode Island Hospital
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
?
mi
from
Providence, RI
Click here to add this to my saved trials
UC Davis Medical Center
Sacramento, California 95814
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Tampa General Hospital
1 Tampa General Cir
Tampa, Florida 33606
(813) 844-7000
Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
?
mi
from
Tampa, FL
Click here to add this to my saved trials
University of South Florida
4202 E Fowler Ave
Tampa, Florida 33620
(813) 974-2011
University of South Florida The University of South Florida is a high-impact, global research university...
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Children's Healthcare of Atlanta/Aflac Cancer and Blood Disorders Center
Atlanta, Georgia 30303
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Children's Healthcare of Atlanta/Aflac Cancer and Blood Disorders Center
Atlanta, Georgia 30303
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Emory Children's Center
Atlanta, Georgia 30322
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Children's Healthcare of Atlanta/Aflac Cancer and Blood Disorders Center
Atlanta, Georgia 30303
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Grady Health System
Atlanta, Georgia 30303
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Children's Healthcare of Atlanta
1405 Clifton Road NE
Atlanta, Georgia 30322
404-785-6000
Children's Healthcare of Atlanta Whether treating a toddler in an emergency or supporting a teen...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Children's Healthcare of Atlant a Aflac Cancer and Blood Disorders Center / Scottish Rite Outpatient
Atlanta, Georgia 30342
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Augusta University Medical Center
Augusta, Georgia 30912
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Augusta University
Augusta, Georgia 30912
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Augusta University Clinical Research Pharmacy
1120 15th Street
Augusta, Georgia 30912
?
mi
from
Augusta, GA
Click here to add this to my saved trials
University of Colorado CTRC
Aurora, Colorado 80045
?
mi
from
Aurora, CO
Click here to add this to my saved trials
University of Colorado Hospital
12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Johns Hopkins Medicine
Baltimore, Maryland 21231
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Johns Hopkins Hospital
1800 Orleans St.
Baltimore, Maryland 21287
410-955-5000
Johns Hopkins Hospital Patients are the focus of everything we do at The Johns Hopkins...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Johns Hopkins University School of Medicine
733 North Broadway
Baltimore, Maryland 21205
(410) 955-3182
Johns Hopkins University School of Medicine Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Johns Hopkins Medicine
Baltimore, Maryland 21231
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
University of Maryland Medical System Investigational Pharmacy
22 S Greene St
Baltimore, Maryland 21201
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
University of Maryland Medical System
Baltimore, Maryland 21201
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
St. Jude Affiliate Clinic
Baton Rouge, Louisiana 70808
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Our Lady of the Lake Physician Group-Medical Oncology
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Our Lady of the Lake Regional Medical Center
Baton Rouge, Louisiana
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Boston Children's Hospital
300 Longwood Ave
Boston, Massachusetts 02115
(617) 355-6000
Boston Children's Hospital Boston Children's Hospital is a 395-bed comprehensive center for pediatric health care....
?
mi
from
Boston, MA
Click here to add this to my saved trials
Boston Medical Center E7E
Boston, Massachusetts 02118
?
mi
from
Boston, MA
Click here to add this to my saved trials
Boston Med Ctr
Boston, Massachusetts 02118
?
mi
from
Boston, MA
Click here to add this to my saved trials
Boston University Medical Center
1 Boston Medical Center Place
Boston, Massachusetts 02118
617.638.8000
Boston University Medical Center Boston Medical Center is an extraordinary community of health care providers...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Center for Clinical Investigation, Brigham and Women's Hospital
75 Francis Street
Boston, Massachusetts 02115
?
mi
from
Boston, MA
Click here to add this to my saved trials
Investigational Drug Services
Boston, Massachusetts 02115
?
mi
from
Boston, MA
Click here to add this to my saved trials
Jacobi Medical Center
1400 Pelham Parkway South
Bronx, New York 10461
(718) 918-5000
Jacobi Medical Center In 1955, the NYC Department of Hospitals opened a new, specialized care...
?
mi
from
Bronx, NY
Click here to add this to my saved trials
Kings County Hospital Center
Brooklyn, New York 11203
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Kings County Hospital Center - Pharmacy Department
Brooklyn, New York 11203
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
State University of New York (SUNY)-Downstate Medical Center
Brooklyn, New York
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Downstate Medical Center State Univ of NY HLTH SCI CTR PHMCY
450 Clarkson Avenue
Brooklyn, New York 11203
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Medical University of South Carolina Hospital
Charleston, South Carolina 29403
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
MUSC, Investigational Drug Services
Charleston, South Carolina 29425
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Medical University of South Carolina Lifespan Comprehensive Sickle Cell Center
Charleston, South Carolina 29425
?
mi
from
Charleston, SC
Click here to add this to my saved trials
University of Chicago, Investigational Drug Service Pharmacy
Chicago, Illinois 60637
?
mi
from
Chicago, IL
Click here to add this to my saved trials
University of Illinois at Chicago Clinical Research Center
Chicago, Illinois 60612
?
mi
from
Chicago, IL
Click here to add this to my saved trials
University of Illinois Hospital & Health Sciences System
Chicago, Illinois 60612
?
mi
from
Chicago, IL
Click here to add this to my saved trials
University of Cincinnati Medical Center/ Investigational Pharmacy
Cincinnati, Ohio 45219
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
University of Cincinnati Medical Center/Research Office
Cincinnati, Ohio 45219
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
University of Cincinnati Physicians Company, LLC
Cincinnati, Ohio 45267
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
University of Cincinnati- Hoxworth Building
Cincinnati, Ohio 45219
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
UC Health Ridgeway Hospital
Cincinnati, Ohio 45229
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
The Ohio State University Investigational Drug Services
Columbus, Ohio 43210
?
mi
from
Columbus, OH
Click here to add this to my saved trials
The Ohio State University James Comprehensive Cancer Hospital & Solove Research Institute
Columbus, Ohio 43210
?
mi
from
Columbus, OH
Click here to add this to my saved trials
The Ohio State University Wexner Medical Center East
Columbus, Ohio 43210
?
mi
from
Columbus, OH
Click here to add this to my saved trials
The Ohio State University, Wexner Medical Center
410 W 10th Ave
Columbus, Ohio 43210
(614) 293-8652
The Ohio State University, Wexner Medical Center Located in Columbus, The Ohio State University Wexner...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Children's Medical Center
Dallas, Texas 75235
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Five Rivers Medical Surgical Health Center
Dayton, Ohio 45402
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Miami Valley Hospital
1 Wyoming St,
Dayton, Ohio 45409
(937) 208-8000
Miami Valley Hospital Miami Valley Hospital (MVH) is passionate about providing the most recent medical...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Children's Hospital of Michigan
3901 Beaubien St
Detroit, Michigan 48201
(313) 745-5437
Children's Hospital of Michigan Since 1886, the Children's Hospital of Michigan has been dedicated to...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Detroit Medical Center Pharmacy
Detroit, Michigan 48201
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Wayne State University/Detroit Receiving Hospital
Detroit, Michigan 48201
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
?
mi
from
Durham, NC
Click here to add this to my saved trials
Duke University Hospital
Durham, North Carolina 27705
?
mi
from
Durham, NC
Click here to add this to my saved trials
Royal Alexandra Hospital
Edmonton, Alberta
?
mi
from
Edmonton,
Click here to add this to my saved trials
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida 33908
?
mi
from
Fort Myers, FL
Click here to add this to my saved trials
Cook Children's Hematology/Oncology Center
Fort Worth, Texas 76104
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Cook Children's Medical Center
801 7th Avenue
Fort Worth, Texas 76104
(682) 885-4000
Cook Children's Medical Center Cook Children's Health Care System is a not-for-profit, nationally recognized pediatric...
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
UF Health Davis Cancer Pavillion and Shands Med Plaza
Gainesville, Florida 32608
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
UF Health Shands Cancer Hospital
Gainesville, Florida 32608
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
UF Health Shands Hospital
Gainesville, Florida 32610
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
Cook Children's Hematology/Oncology Center-Grapevine
Grapevine, Texas
?
mi
from
Grapevine, TX
Click here to add this to my saved trials
East Carolina University Brody School of Medicine
Greenville, North Carolina
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Leo W. Jenkins Cancer Center
Greenville, North Carolina 27834
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Vidant Medical Center
Greenville, North Carolina 27834
?
mi
from
Greenville, NC
Click here to add this to my saved trials
East Carolina University
1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
?
mi
from
Greenville, NC
Click here to add this to my saved trials
UT Physicians Comprehensive Sickle Cell Center Houston
Houston, Texas 77004
?
mi
from
Houston, TX
Click here to add this to my saved trials
Memorial Hermann - TMC Investigational Drugs, IDS Pharmacy
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Memorial Hermann Hospital, Texas Medical Center - Clinical Research Unit (CRU)
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Memorial Hermann/UT Cancer Center - Texas Medical Center
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
University of Texas Medical School
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Texas Children´s Hospital - Investigational Pharmacy
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Texas Children´s Hospital - Main Hospital
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Texas Children's Hospital- Wallace Tower
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
University of Mississippi Medical Center-Outpatient Clinical Research Unit
2500 North State Street
Jackson, Mississippi 39216
?
mi
from
Jackson, MS
Click here to add this to my saved trials
Children´s Mercy Hospital
2401 Gillham Road
Kansas city, Missouri 64108
?
mi
from
Kansas city, MO
Click here to add this to my saved trials
Arkansas Children's Hospital Research Pharmacy
1 Children's Way
Little Rock, Arkansas 72202
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Arkansas Children's Hospital
1 Children's Way
Little Rock, Arkansas 72202
(501) 364-1100
Arkansas Children's Hospital Arkansas Children's Hospital (ACH) is the only pediatric medical center in Arkansas...
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Kosair Charities Pediatric Clinical Research Unit
Louisville, Kentucky 40202
?
mi
from
Louisville, KY
Click here to add this to my saved trials
University of Louisville Health Sciences Center
Louisville, Kentucky 40205
?
mi
from
Louisville, KY
Click here to add this to my saved trials
University of Louisville Physicians Pediatric Hematology Oncology
Louisville, Kentucky 40202
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Norton Children´s Hospital
Louisville, Kentucky 40202
?
mi
from
Louisville, KY
Click here to add this to my saved trials
University of South Alabama, Children's and Women's Hospital
Mobile, Alabama 36604
?
mi
from
Mobile, AL
Click here to add this to my saved trials
The Bristol-Myers Squibb Children's Hospital at Robert Wood Johnson University Hospital
New Brunswick, New Jersey 08901
?
mi
from
New Brunswick, NJ
Click here to add this to my saved trials
Rutgers Robert Wood Johnson Medical School
New Brunswick, New Jersey 08903
?
mi
from
New Brunswick, NJ
Click here to add this to my saved trials