Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine
| Status: | Completed |
|---|---|
| Conditions: | Migraine Headaches |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 9/2/2018 |
| Start Date: | March 2015 |
| End Date: | October 2016 |
Hydromorphone Versus Prochlorperazine + Diphenhydramine for Treatment of Acute Migraine. A Randomized, Emergency Department Based, Comparative Efficacy Study
Opioids are commonly used to treat migraine in North American Emergency Departments. We are
comparing efficacy and adverse events of hydromorphone, an opioid, to that of
prochlorperazine, a dopamine antagonist with known efficacy in migraine. Prochlorperazine
will be combined with diphenhydramine to prevent adverse events.
comparing efficacy and adverse events of hydromorphone, an opioid, to that of
prochlorperazine, a dopamine antagonist with known efficacy in migraine. Prochlorperazine
will be combined with diphenhydramine to prevent adverse events.
Inclusion Criteria:
- Migraine headache (International Classification of Headache Disorders 3B criteria)
Exclusion Criteria:
- Brain imaging ordered
- Fever
- Objective neurological findings
- Pregnancy/ breast feeding
- Allergy/ contraindication to investigational medication
- History of addiction to opioids, use of methadone, any use of opioids previous 30 days
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